Results 11 to 20 of about 1,679,926 (396)

Mechanism of fatty acid synthesis*

Journal of Lipid Research, 1961
Salih J. Wakil
doaj   +2 more sources

Fatty Acid Synthesis in Prostate Cancer: Vulnerability or Epiphenomenon?

Cancer Research, 2021
Tumor metabolism supports the energetic and biosynthetic needs of rapidly proliferating cancer cells and modifies intra- and intercellular signaling to enhance cancer cell invasion, metastasis, and immune evasion.
Laura A. Sena, S. Denmeade
semanticscholar   +1 more source

SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. [PDF]

PLoS ONE, 2012
Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid metabolism, we evaluated various nodes of the fatty acid synthesis pathway.
Paul Mason, Beirong Liang, Lingyun Li, Trisha Fremgen, Erin Murphy, Angela Quinn, Stephen L Madden, Hans-Peter Biemann, Bing Wang, Aharon Cohen, Svetlana Komarnitsky, Kate Jancsics, Brad Hirth, Christopher G F Cooper, Edward Lee, Sean Wilson, Roy Krumbholz, Steven Schmid, Yibin Xiang, Michael Booker, James Lillie, Kara Carter   +21 more
doaj   +1 more source

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria

eLife, 2020
Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS).
Sara M. Nowinski, Ashley Solmonson, S. Rusin, J. Maschek, C. Bensard, S. Fogarty, Mi-Young Jeong, Sandra Lettlova, J. A. Berg, J. Morgan, Yeyun Ouyang, Bradley C. Naylor, J. Paulo, K. Funai, J. Cox, S. Gygi, D. Winge, R. Deberardinis, J. Rutter   +18 more
semanticscholar   +1 more source

Inhibiting Bacterial Fatty Acid Synthesis [PDF]

Journal of Biological Chemistry, 2006
The type II fatty acid synthase consists of a series of individual enzymes, each encoded by a separate gene, that catalyze discrete steps in chain elongation. The formation of fatty acids is vital to bacteria, and each of the essential enzymes and their acyl group carriers represent a potential target for the development of novel antibacterial ...
Yong-Mei, Zhang, Stephen W, White, Charles O, Rock   +2 more
openaire   +2 more sources

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance [PDF]

, 2014
Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle
Aguirre, Antonescu, Bain, Boppart, Cancello, Cao, Carlson, Caroline P. Wheeler-Jones, Cazzolli, Chavez, Cleasby, Coll, Corraliza, de Alvaro, De Paepe, Devaraj, Diamond-Stanic, Dimopoulos, Elgazar-Carmon, Festa, Fink, Fujishiro, Gao, Griffin, Haversen, Hemi, Hevener, Hirabara, Hirosumi, Hoehn, Hommelberg, Hotamisligil, Hotamisligil, Hwang, Kadotani, Karten, Kewalramani, Kuma, Lee, Lee, Liang, Lumeng, Lumeng, Maekawa, Mark E. Cleasby, McCall, Nguyen, Nicola A. Talbot, Patel, Pillon, Pinnick, Plomgaard, Polkinghorne, Prieur, Samokhvalov, Schilling, Sell, Shi, Solinas, Storlien, Suganami, Tardif, Thong, Turner, Uysal, Varma, Weisberg, Yuan   +67 more
core   +2 more sources

Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver.

Journal of Lipid Research, 1984
In a series of experiments with male rat livers perfused with or without 5-tetradecyloxy-2-furoic acid (TOFA) in the presence and absence of oleate, the relationships between fatty acid synthesis, oxidation, and esterification from newly synthesized and ...
N Fukuda, J A Ontko
doaj   +1 more source

Chloroplast damage induced by the inhibition of fatty acid synthesis triggers autophagy in chlamydomonas [PDF]

, 2018
Fatty acids are synthesized in the stroma of plant and algal chloroplasts by the fatty acid synthase complex. Newly synthesized fatty acids are then used to generate plastidial lipids that are essential for chloroplast structure and function.
Andrés Garrido, Ascensión, Crespo González, José Luis, Heredia Martínez, Luis G., Martínez Force, Enrique, Pérez Pérez, Maria Esther   +4 more
core   +1 more source

Enterococcus faecalis Encodes an Atypical Auxiliary Acyl Carrier Protein Required for Efficient Regulation of Fatty Acid Synthesis by Exogenous Fatty Acids

mBio, 2019
Acyl carrier proteins (ACPs) play essential roles in the synthesis of fatty acids and transfer of long fatty acyl chains into complex lipids. The Enterococcus faecalis genome contains two annotated acp genes, called acpA and acpB.
Lei Zhu, Qi Zou, Xinyun Cao, John E. Cronan   +3 more
doaj   +1 more source

Effect of Wakame and Carob Pod Snacks on Non-Alcoholic Fatty Liver Disease [PDF]

, 2019
Snacks combining different functional ingredients could represent a useful therapeutic strategy against NAFLD. The present study aimed to analyze the effect of two snack formulations based on carob and wakame flour in the treatment for NAFLD in rats. For
Aguirre López, Leixuri, De Luis Román, Daniel Antonio, Lasa Elguezua, Arrate, Martín Diana, Ana Belén, Milton Laskibar, Iñaki, Miranda Gómez, Jonatan, Rico Bargues, Daniel   +6 more
core   +2 more sources