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HIF2α Promotes Cancer Metastasis through TCF7L2-Dependent Fatty Acid Synthesis in ccRCC. [PDF]
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REGULATION OF FATTY ACID SYNTHESIS
Annual Review of Plant Physiology and Plant Molecular Biology, 1997▪ Abstract All plant cells produce fatty acids from acetyl-CoA by a common pathway localized in plastids. Although the biochemistry of this pathway is now well understood, much less is known about how plants control the very different amounts and types of lipids produced in different tissues.
Jan G. Jaworski, John B. Ohlrogge
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Mechanism of fatty acid synthesis
Life Sciences, 1977Abstract Significant advances have been made in the past few years in our understanding of the mechanism of synthesis of fatty acids, the structural organization of fatty acid synthetase complexes and the mechanism of regulation of activity of these enzyme systems.
Sarvagya S. Katiyar, John W. Porter
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Synthesis of the fatty acid of pramanicin [PDF]
Canadian Journal of Chemistry, 1997 The natural product tetradec-2-enoic acid-4,5-epoxide (2), which is also a component of the antibiotic pramanicin (1), was prepared in racemic form by a glycoluril-template directed approach. Two sequential additions of acetate units to decanoic acid are effected by intramolecular condensations on the template, mimicking the proposed biosynthetic ...
David Valentini +2 more
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1970
Abstract 1. 1. The fatty-acid synthesizing capacity of guinea-pig heart is confined to the mitochondria; no synthesis of fatty acid could be demonstrated in the microsomal or soluble fractions. 2. 2. ATP citrate lyase (EC 4.1.3.8) and acetyl-CoA carboxylase (EC 6.4.1.2), which in rat liver were localized in the non-particulate fraction of the
H.L. Elenbaas +2 more
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Abstract 1. 1. The fatty-acid synthesizing capacity of guinea-pig heart is confined to the mitochondria; no synthesis of fatty acid could be demonstrated in the microsomal or soluble fractions. 2. 2. ATP citrate lyase (EC 4.1.3.8) and acetyl-CoA carboxylase (EC 6.4.1.2), which in rat liver were localized in the non-particulate fraction of the
H.L. Elenbaas +2 more
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Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017Mitochondria and fatty acids are tightly connected to a multiplicity of cellular processes that go far beyond mitochondrial fatty acid metabolism. In line with this view, there is hardly any common metabolic disorder that is not associated with disturbed mitochondrial lipid handling. Among other aspects of mitochondrial lipid metabolism, apparently all
Anne M. Mäkelä +10 more
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Enzymatic synthesis of fatty acids
Comparative Biochemistry and Physiology, 1962Abstract Available evidence indicates that there are two distinct systems for the synthesis of fatty acids. 1—The mitochondrial system which may involve some enzymes of the β-oxidation system plus TPNH-α-β-unsaturated acyl reductase and perhaps a new condensing enzyme. Both TPNH and DPNH are required for the synthesis.
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Studies on the mechanism of fatty acid synthesis III. Products of enzymic synthesis of fatty acids
Biochimica et Biophysica Acta, 1957Abstract The long-chain fatty acids synthesized from acetate by an enzyme system reconstructed fom soluble fractions of pigeon liver have been separated and identified by a variety of techniques. Free palmitic acid and progressively smaller amounts of free myristic, lauric and decanoic acids are principally formed in this system.
John W. Porter, Alisa Tietz
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Synthesis of unsaturated fatty acids
Chemistry and Physics of Lipids, 1973Abstract This article reviews synthetic routes leading to polyunsaturated fatty acids having “skipped” double bonds. Emphasis is placed on the “acetylenic approach”. The suitability of building blocks, their condensation reactions as well as the controlled reduction of triple bonds to cis double bonds are discussed. In addition, the application of
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