Results 31 to 40 of about 1,679,926 (396)

Differential Regulation of Human Treg and Th17 Cells by Fatty Acid Synthesis and Glycolysis

Frontiers in Immunology, 2019
In this study we examined the metabolic requirements of human T helper cells and the effect of manipulating metabolic pathways in Th17 and Treg cells.
D. Cluxton, A. Petrasca, B. Moran, J. Fletcher   +3 more
semanticscholar   +1 more source

Metabolic and Molecular Regulation of Dietary Polyunsaturated Fatty Acids on Prostate Cancer [PDF]

, 2015
Purpose The aim of this study is to investigate the role of n-3 and n-9 fatty acids in crucial processes involved in prostate cancer cell growth through a large-scale proteomic analysis.
Lai, Xianyin, Pflug, Beth R., Wang, Mu, Zhao, Heng   +3 more
core   +1 more source

Glioma Stem Cell Specific Super Enhancer Promotes Polyunsaturated Fatty Acid Synthesis to Support EGFR Signaling.

Cancer Discovery, 2019
Glioblastoma ranks among the most aggressive and lethal of all human cancers. Functionally defined glioma stem cells (GSCs) contribute to this poor prognosis by driving therapeutic resistance and maintenance of cellular heterogeneity.
Ryan C. Gimple, Reilly L. Kidwell, Leo J. Y. Kim, Tengqian Sun, Anthony D. Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, S. Bhargava, Li Jiang, B. Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, A. Sloan, P. Mischel, J. M. Brown, Hu Cang, T. Huan, S. Mack, Qi Xie, J. Rich   +26 more
semanticscholar   +1 more source

Decreased hepatic production of very low density lipoproteins following activation of fatty acid oxidation by Ro 22-0654.

Journal of Lipid Research, 1985
In fed rat livers perfused with [1-14C]oleic acid, Ro 22-0654 (4-amino-5-ethyl-3-thiophenecarboxylic acid methyl ester hydrochloride), an inhibitor of fatty acid synthesis, activated ketogenesis and decreased the secretion of triglyceride in very low ...
M Yamamoto, N Fukuda, J Triscari, A C Sullivan, J A Ontko   +4 more
doaj   +1 more source

LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis

Signal Transduction and Targeted Therapy, 2019
Ferroptosis is a form of regulated necrotic cell death characterized by an iron-dependent lipid peroxidation. Although mounting evidence has demonstrated that diverse cellular metabolic processes contribute to ferroptosis, the detail mechanism by which ...
Changzhi Li, Xuan Dong, W. Du, Xingwang Shi, Kangjie Chen, Wei Zhang, Minghui Gao   +6 more
semanticscholar   +1 more source

The absolute rate of fatty acid synthesis by mammary gland slices from lactating rats

Journal of Lipid Research, 1976
Mammary gland utilizes a combination of substrates in vivo. To determine if and how the substrates presented to the gland alter milk fat synthesis, slices of mammary gland of lactating rats were incubated with combinations of glucose, L-lactate, and ...
J C Bartley, S Abraham
doaj   +1 more source

Trehalose 6-Phosphate Positively Regulates Fatty Acid Synthesis by Stabilizing WRINKLED1[OPEN]

The Plant Cell, 2018
Trehalose 6-phosphate binds to the KIN10 subunit of SnRK1 and inhibits it in a GRIK-dependent manner, positively regulating fatty acid synthesis by stabilizing WRINKLED1.
Zhiyang Zhai, J. Keereetaweep, Hui Liu, R. Feil, J. Lunn, J. Shanklin   +5 more
semanticscholar   +1 more source

Role of fatty acid synthesis in the control of insulin-stimulated glucose utilization by rat adipocytes.

Journal of Lipid Research, 1981
A decreased capacity for fatty acid synthesis is associated with a decreased insulin effect on glucose metabolism in large fat cells and fat cells from rats fed a high-fat diet.
S K Fried, M Lavau, F X Pi-Sunyer
doaj   +1 more source

Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

Science Translational Medicine, 2020
A glycine- and leucine-based tripeptide improves symptoms in a mouse model of nonalcoholic fatty liver disease, which lacks approved treatments. Amino acids alleviate liver disease Glycine is known to be reduced in patients with nonalcoholic fatty liver ...
O. Rom, Yuhao Liu, Zhipeng Liu, Ying Zhao, Jianfeng Wu, Alia Ghrayeb, L. Villacorta, Yanbo Fan, Lin Chang, Lu Wang, Cai Liu, Dongshan Yang, Jun Song, J. Rech, Yanhong Guo, Huilun Wang, Guizhen Zhao, Wenying Liang, Yui Koike, Haocheng Lu, T. Koike, T. Hayek, T. Hayek, S. Pennathur, C. Xi, Bo Wen, Duxin Sun, Minerva T. Garcia-Barrio, M. Aviram, E. Gottlieb, I. Mor, Wanqing Liu, Jifeng Zhang, Y. E. Chen   +33 more
semanticscholar   +1 more source

The Two Functional Enoyl-Acyl Carrier Protein Reductases of Enterococcus faecalis Do Not Mediate Triclosan Resistance

mBio, 2013
Enoyl-acyl carrier protein (enoyl-ACP) reductase catalyzes the last step of the elongation cycle in the synthesis of bacterial fatty acids. The Enterococcus faecalis genome contains two genes annotated as enoyl-ACP reductases, a FabI-type enoyl-ACP ...
Lei Zhu, Hongkai Bi, Jincheng Ma, Zhe Hu, Wenbin Zhang, John E. Cronan, Haihong Wang   +6 more
doaj   +1 more source