Results 51 to 60 of about 619,233 (330)

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Brain food for babies [PDF]

, 2017
How does a mother supply a key building block of the brain required for neurodevelopment to her fetus in pregnancy? The critical requirement of docosahexaenoic acid (DHA) for fetal brain development, and the poor efficiency of its synthesis in humans, is
Freeman, Dilys J., Meyer, Barbara J.
core  

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Resveratrol Modulates Desaturase Expression and Fatty Acid Composition of Cultured Hepatocytes

Frontiers in Nutrition, 2018
This study aimed to evaluate whether resveratrol (RSV) and its microbial metabolites dihydro-resveratrol (DHR) and lunularin (LUN) affected fatty acid metabolism and omega-3 polyunsaturated fatty acid (n3-PUFA) synthesis in cultured hepatocytes.
Gianna Kühn, Kathrin Pallauf, Carsten Schulz, Carsten Schulz, Marc Birringer, Beatriz Diaz-Rica, Sonia de Pascual-Teresa, Gerald Rimbach   +7 more
doaj   +1 more source

Fatty Acid Synthesis by Extracts of Euglena [PDF]

Plant Physiology, 1965
At least 3 known pathways are available to a cell to synithesize satuirated fatty acids: A) the malonylCoA pathwav which has been shown to result in do novo synthesis of long-chain fatty acids, B) reversal of the fl-oxidation pathway which results primarily in syinthesis of short-chain acids and onlv negligible amounlits of long-chain fatty acids.
Pat Carey Kerr, George M. Cheniae
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Post-heparin phospholipase and fatty acid transesterification in human plasma

Journal of Lipid Research, 1965
The incubation of post-heparin plasma and egg phosphatidyl ethanolamine in the presence of methanol, ethanol, or glycerol resulted in the synthesis of fatty acid esters of these alcohols.
William C. Vogel, Will G. Ryan, J.L. Koppel, J.H. Olwin   +3 more
doaj   +1 more source

Effect of supplementation with different fat sources on the mechanisms involved in reproductive performance in lactating dairy cattle [PDF]

, 2012
peer reviewedSupplementary fat positively influences reproductive performance in dairy cattle, although the mechanisms involved are not clearly defined. Our objective was to determine the effects of four different fat supplements on follicle development,
Butler, Stephen, Dewhurst, Richard J., Evans, A.C.O., Hennessy, Alan A., Hutchinson, Ian A., Lonergan, P., Waters, Sinead M.   +6 more
core   +1 more source

The Regulation of Fatty Acid Synthesis in Human Skin Fibroblasts

Journal of Biological Chemistry, 1973
Abstract The short term regulation of fatty acid biosynthesis has been studied using primary cultures of human skin fibroblasts. These cells show rapid changes in rates of acetate incorporation into fatty acids depending upon the lipid content of the medium.
Philip W. Majerus, Richard A. Jacobs
openaire   +3 more sources

Control of fatty acid synthesis in lactation [PDF]

Proceedings of the Nutrition Society, 1983
Lactation results not only in an increased rate of fatty acid synthesis in the mammary gland but also in a decreased rate of fatty acid synthesis in adipose tissue and, in the rat at least, an increased rate of hepatic fatty acid synthesis. Progesterone (during pregnancy), prolactin and (in ruminants) GH are implicated in the regulation of the ...
R G Vernon, D J Flint
openaire   +3 more sources