Results 121 to 130 of about 888,881 (286)

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Full arthroscopic latissimus dorsi and teres major tendons transfer for massive and irreparable rotator cuff defects: mid-term outcomes

Travmatologiâ i Ortopediâ Rossii
Background. Treatment of massive irreparable rotator cuff tears remains a challenging clinical problem. Recent advances in arthroscopic techniques have improved functional outcomes and broadened the indications for musculotendinous transfers, which are ...
Roman V. Gladkov, Aleksander K. Dulaev, Alexandr A. Hajrutdinov, Igor O. Shevchuk   +3 more
doaj   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Intramuscular distribution and progression of fatty infiltration.

, 2014
Transveral T1 weighted images at different positions of the thigh of a FSHD patient. Baseline measurement (left panels) reveals an uneven distruibution over the length of the muscle with an increasing fat infiltration from proximal (top) to distal ...
Nicoline B. M. Voet (508938), Jacky W. J. de Rooy (508940), Barbara H. Janssen (508937), Christine I. Nabuurs (508939), Baziel G. M. van Engelen (399109), Alexander C. Geurts (508941), George W. Padberg (399110), Hermien E. Kan (464691), Arend Heerschap (385175)   +8 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Fatty infiltration of the cervical extensor musculature, cervical sagittal balance, and clinical outcomes: An analysis of operative adult cervical deformity patients.

, 2020
PURPOSE: To assess preliminary associations between fatty-infiltration (FI) of cervical spine extensor musculature, cervical sagittal balance, and clinical outcomes in cervical deformity (CD) patients. METHODS: Operative CD patients (C2-C7 Cobb \u3e 10°,
Hamilton, D Kojo, Schwab, Frank J, Bortz, Cole, Lafage, Virginie, Bess, Shay, Passias, Peter G, Sciubba, Daniel M, Burton, Douglas C, Segreto, Frank A, Naessig, Sara, Ames, Christopher P, Horn, Samantha R, Hart, Robert A, Lafage, Renaud, Klineberg, Eric O, Shaffrey, Christopher I, Neuman, Brian J, Diebo, Bassel G, Nunley, Pierce, Smith, Justin S   +19 more
core   +1 more source

Lower trapezius tendon transfer for massive irreparable rotator cuff tears improves outcomes in patients with high grade fatty infiltration of teres minor

JSES International
Background: This study compares postoperative outcomes of lower trapezius tendon transfers (LTTTs) in massive irreparable rotator cuff (RC) tears based on the degree of teres minor (TM) fatty infiltration.
Eva Gusnowski, MD, FRCSC, Eric Wagner, MD, Sheila McRae, PhD, Hayden Cooke, MD, Anthony Karzon, MD, Michael Gottschalk, MD, Peter MacDonald, MD, FRCSC, Jarret Woodmass, MD, FRCSC   +7 more
doaj   +1 more source

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

Advanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia, Jingshang Wen, Jihang Li, Meina Feng, Yiming He, Ruojun Liu, Qian Liu, Junli Zhang, Kai Cheng, Xiangyu Zhang, Xiao Zhang   +10 more
wiley   +1 more source

Fatty infiltration of the liver in hunger [PDF]

The Journal of Physiology, 1909
openaire   +2 more sources

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source