Results 121 to 130 of about 472,072 (313)

Postprandial Dysmetabolism and Non-Alcoholic Fatty Liver Disease in Relation to Type 2 Diabetes Mellitus and Cardiovascular Risk [PDF]

, 2007
Het aantal gevallen van “ouderdomssuikerziekte” (type 2 diabetes mellitus) neemt in de Westerse wereld snel toe als gevolg van veranderingen in leefstijl (verhoogde consumptie van vet- en energierijke voeding en verminderde lichaamsbeweging), en als ...
Schindhelm, R.K.
core  

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, Volume 36, Issue 44, 1 June 2026.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications

Advanced Functional Materials, EarlyView.
Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi, Norma Mallegni, Andrea Dorigato, Mario Milazzo   +3 more
wiley   +1 more source

Copolymers of Poly(Butylene Trans‐1,4‐Cyclohexanedicarboxylate)/Pripol as New Biomaterial Platform for Small Diameter Vascular Graft

Advanced Healthcare Materials, EarlyView.
Electrospun tubular scaffolds from novel PBCE‐based copolyesters and blends were designed as candidates for small‐diameter vascular grafts. They combine defect‐free architecture, blood‐compatible surfaces, and mechanical properties comparable to native vessels.
Edoardo Bondi, Gabriele Obino, Giulia Guidotti, Alberto Sensini, Martijn van Griensven, Antonio Junior Lepedda, Nadia Lotti, Lorenzo Moroni   +7 more
wiley   +1 more source

Liver disease, the Swiss army knife of comorbidity: A patient perspective from the grass roots

Endocrinology, Diabetes & Metabolism, 2020
Wayne Eskridge
doaj   +1 more source

Carfilzomib activates ER stress and JNK/p38 MAPK signaling to promote apoptosis in hepatocellular carcinoma cells

Acta Biochimica et Biophysica Sinica
Hepatocellular carcinoma (HCC) is one of the most prevalent and deadly cancers in the world, which is frequently diagnosed at a late stage. HCC patients have a poor prognosis due to the lack of an efficacious therapeutic strategy.
Deng Yao, Li Yujie, Yang Mingyue, Gao Yang, Luo Xuling, Chen Hanbin, Guo Meng, Yang Xuefeng, Liu Yongzhang, He Jun, Lu Bin, Liu Naxin   +11 more
doaj   +1 more source

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

What is non-alcoholic fatty liver disease (NAFLD), and why is it important?

, 2015
Fatty liver is defined pathologically by stainable fat in hepatocytes (steatosis), or biochemically by hepatic triglyceride content exceeding 5.5%. Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent disorder in which over-nutrition leads to
McCullough, Arthur, Day, Christopher, Farrell, Geoffrey   +2 more
core  

Gallstone Disease Does Not Predict Liver Histology in Nonalcoholic Fatty Liver Disease

, 2014
Background/Aims: We sought to examine whether the presence of gallstone disease (GD) in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) is associated with liver fibrosis and histological nonalcoholic steatohepatitis (NASH) score ...
YILMAZ, YUSUF
core   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source