Results 131 to 140 of about 2,963,117 (406)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Global assessment of hepatic safety in novel immunotherapies: a systematic review and meta-analysis

Frontiers in Immunology
BackgroundThis study explored whether integrating innovative immunotherapies targeting costimulatory or co-inhibitory pathways beyond standard PD-1, PD-L1, and CTLA-4 treatments affects hepatic adverse events.
Minyan Ye, Yinuo Dong, Xiaoyun Li, Xiaoyun Li, Yang Zhi, Yuping Lu, Jieting Tang, Wei Zhong, Xiaohong Lei, Yimin Mao, Sha Huang, Yanyan Song   +11 more
doaj   +1 more source

Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity [PDF]

, 2016
Objective: This study aimed to evaluate whether circulating levels and/or visceral adipose tissue (VAT) expression of recently described adipokines associate with histopathological severity of nonalcoholic fatty liver disease (NAFLD), independent of ...
Alfadda, Behari, Bekaert, Bozaoglu, Brunt, Bugianesi, Chakaroun, Deng, Docke, Donnelly, Ehrlund, Fuster, Greulich, Gruben, Haukeland, Heiker, Kanda, Kim, Kleiner, Luangsay, Mahdi, Marchesini, Musso, Ouwens, Polyzos, Polyzos, Rivera, Saxena, Seki, Sell, Sell, Souza Batista, Wittamer, Wittamer, Wolfs, Wong, Yang, Yilmaz, Zelber-Sagi, Zeng   +39 more
core   +1 more source

Nonalcoholic fatty liver disease

Annals of Hepatology, 2004
Nonalcoholic fatty liver disease is a clinicopathologic syndrome that encompasses several clinical entities. The spectrum of conditions ranges from simple steatosis to steatohepatitis, fibrosis and end stage liver disease. The condition was originally described in obese, diabetic, middle-aged females without a history of significant alcohol use with ...
Lafaine M. Grant, Mauricio Lisker-Melman
openaire   +3 more sources

AASLD practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease.

Hepatology, 2023
M. Rinella, B. Neuschwander‐Tetri, M. Siddiqui, M. Abdelmalek, S. Caldwell, D. Barb, D. Kleiner, R. Loomba   +7 more
semanticscholar   +1 more source

Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.

Gastroenterology, 2019
BACKGROUND & AIMS We estimated the accuracy of FibroScan vibration-controlled transient elastography controlled attenuation parameter (CAP) and liver stiffness measurement (LSMs) in assessing steatosis and fibrosis in patients with suspected nonalcoholic
P. Eddowes, M. Sasso, M. Allison, E. Tsochatzis, Q. Anstee, D. Sheridan, I. Guha, J. Cobbold, J. Deeks, V. Paradis, P. Bedossa, P. Newsome   +11 more
semanticscholar   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Proximate and fatty acid composition of liver and fatty tissue of patin catfish (Pangasianodon hypophthalmus) [PDF]

, 2014
The visceral storage fat and liver of patin catfish (Pangasianodon hypophthalmus) are normally discarded, which incurs cost and can cause environmental pollution. However, these may be potential sources to extract fish oil.
Christianus, Annie, Ehteshami, Fariborz, Shabani Kakroodi, S., Tan, Chin Ping, Yaakob, Che Man   +4 more
core  

GSH Attenuates Organ Injury and Improves Function after Transplantation of Fatty Livers [PDF]

, 2010
Ischemia-reperfusion injury (IRI) is increased after transplantation of steatotic livers. Since those livers are increasingly used for transplantation, protective strategies must be developed. Reactive oxygen species (ROS) play a key role in hepatic IRI.
Angele, M. K., Bilzer, M., Gruetzner, U., Jauch, Karl-Walter, Löhe, F., Pratschke, S., Schauer, R. J., Tufman, A.   +7 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source