Results 151 to 160 of about 659 (220)

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Scaling and networking a modular photonic quantum computer. [PDF]

Nature
Aghaee Rad H, Ainsworth T, Alexander RN, Altieri B, Askarani MF, Baby R, Banchi L, Baragiola BQ, Bourassa JE, Chadwick RS, Charania I, Chen H, Collins MJ, Contu P, D'Arcy N, Dauphinais G, De Prins R, Deschenes D, Di Luch I, Duque S, Edke P, Fayer SE, Ferracin S, Ferretti H, Gefaell J, Glancy S, González-Arciniegas C, Grainge T, Han Z, Hastrup J, Helt LG, Hillmann T, Hundal J, Izumi S, Jaeken T, Jonas M, Kocsis S, Krasnokutska I, Larsen MV, Laskowski P, Laudenbach F, Lavoie J, Li M, Lomonte E, Lopetegui CE, Luey B, Lund AP, Ma C, Madsen LS, Mahler DH, Mantilla Calderón L, Menotti M, Miatto FM, Morrison B, Nadkarni PJ, Nakamura T, Neuhaus L, Niu Z, Noro R, Papirov K, Pesah A, Phillips DS, Plick WN, Rogalsky T, Rortais F, Sabines-Chesterking J, Safavi-Bayat S, Sazhaev E, Seymour M, Rezaei Shad K, Silverman M, Srinivasan SA, Stephan M, Tang QY, Tasker JF, Teo YS, Then RB, Tremblay JE, Tzitrin I, Vaidya VD, Vasmer M, Vernon Z, Villalobos LFSSM, Walshe BW, Weil R, Xin X, Yan X, Yao Y, Zamani Abnili M, Zhang Y.   +89 more
europepmc   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

In Situ X‐Ray Tomography and Acoustic Emission Monitoring of Damage Evolution in C/C‐SiC Composites Fabricated by Liquid Silicon Infiltration

Advanced Science, EarlyView.
This study investigates how the internal structure of fiber‐reinforced ceramic composites affects their resistance to damage. By combining 3D X‐ray imaging with acoustic emission monitoring during mechanical testing, it reveals how silicon distribution influences crack formation.
Yang Chen, Renato S. M. Almeida, Stefan Flauder, Guillaume Couégnat, Kamen Tushtev, Jürgen Horvath, Peter Wriggers, Kurosch Rezwan   +7 more
wiley   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Hybrid Machine Learning-Based Fault-Tolerant Sensor Data Fusion and Anomaly Detection for Fire Risk Mitigation in IIoT Environment. [PDF]

Sensors (Basel)
Desikan J, Singh SK, Jayanthiladevi A, Bhushan S, Rishiwal V, Kumar M.   +5 more
europepmc   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Experimental memory control in continuous-variable optical quantum reservoir computing. [PDF]

Nat Photonics
Paparelle I, Henaff J, García-Beni J, Gillet É, Montesinos D, Giorgi GL, Soriano MC, Zambrini R, Parigi V.   +8 more
europepmc   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

Advanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong, James Trevarthen, Igor Dolbnya, Wadwan Singhapong, Nicholas Pilato, Richard Butler, Jiraphant Srisuriyachot, Alexander J. G. Lunt   +7 more
wiley   +1 more source

Active multiplexing for scalable generation and manipulation of photonic quantum states. [PDF]

Nano Converg
Kaneda F, Yabuno M.
europepmc   +1 more source