Results 51 to 60 of about 21,616 (213)

Multicast in DKS(N, k, f) Overlay Networks [PDF]

, 2003
Recent developments in the area of peer-to-peer computing show that structured overlay networks implementing distributed hash tables scale well and can serve as infrastructures for Internet scale applications.
Ali Ghodsi, Luc Onana Alima, Per Brand, Sameh El-ansary, Seif Haridi   +4 more
core   +7 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Quantum Computing with Very Noisy Devices

, 2004
In theory, quantum computers can efficiently simulate quantum physics, factor large numbers and estimate integrals, thus solving otherwise intractable computational problems. In practice, quantum computers must operate with noisy devices called ``gates''
A Steane, AM Childs, AM Steane, AM Steane, AY Kitaev, CH Bennett, CH Bennett, D DiVincenzo, D Gottesman, D Gottesman, D Leibfried, DP DiVincenzo, E Knill, E Knill, E Knill, E. Knill, J Preskill, JJ Bollinger, MA Nielsen, PW Shor, PW Shor, R Raussendorf, RP Feynman, X Zhou   +23 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Investigating the Metric and Fault-Tolerant Dimensions in Para-Line Network Topologies

AKCE International Journal of Graphs and Combinatorics
The resolving set (RS) and metric dimension (MD) are critical concepts used in various fields such as computer networks, robot navigation, chemical structures, communication networks, transportation, and electric circuits.
M. Faheem, M. Ahmad, Z. Zahid, Njood. S. E. ALmutire, Hamiden Abd El-Wahed Khalifa, Taha Radwan   +5 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Cross-Domain Discovery of Communication Peers. Identity Mapping and Discovery Services (IMaDS)

, 2017
The upcoming WebRTC-based browser-to-browser communication services present new challenges for user discovery in peer-to-peer mode. Even more so, if we wish to enable different web communication services to interact.
Beierle, Felix, Copeland, Rebecca, Crom, Jean-Michel, Friese, Ingo, Göndör, Sebastian, Küpper, Axel, Pereira, Ricardo Lopes   +6 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source