Results 51 to 60 of about 138,506 (269)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

An adaptive reclosing scheme for flexible DC grid based on residual voltage S-transformation

Scientific Reports
When a fault occurs on a line, it is necessary to quickly isolate the fault to improve the safety and reliability of the transmission system. Due to the lack of effective ability to identify the nature of faults, the traditional automatic reclosing ...
Yue Dai, Hongchun Shu, Na An, Yutao Tang, Yiming Han   +4 more
doaj   +1 more source

A Survey on Gas Leakage Source Detection and Boundary Tracking with Wireless Sensor Networks

IEEE Access, 2016
Gas leakage source detection and boundary tracking of continuous objects have received a significant research attention in the academic as well as the industries due to the loss and damage caused by toxic gas leakage in large-scale petrochemical plants ...
Lei Shu, Mithun Mukherjee, Xiaoling Xu, Kun Wang, Xiaoling Wu   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

MULTIFUNCTIONAL LAND USE IN THE RENEWAL OF HARBOUR AREAS: PATTERNS OF PHYSICAL DISTRIBUTION OF THE URBAN FUNCTIONS

On the W@terfront, 2004
Being one of the most representative spatial processes of the last 30 years, which frequently occur in strategic parts of the cities and justify special financing investments, the operations of renewal of harbour areas can be seen as a laboratory of ...
JOÃO PEDRO Costa, Antoni Remesar
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Concurrent Fault Diagnosis for Rotating Machinery Based on Vibration Sensors

International Journal of Distributed Sensor Networks, 2013
Rotating machinery is widely used in modern industry. It is one of the most critical components in a variety of machinery and equipment. Along with the continuous development of science and technology, the structures of rotating machinery become of ...
Qing-Hua Zhang, Qin Hu, Guoxi Sun, Xiaosheng Si, Aisong Qin   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

WSNs-Based Mechanical Equipment State Monitoring and Fault Diagnosis in China

International Journal of Distributed Sensor Networks, 2015
Wireless sensor networks (WSNs) have been used in the state monitoring and fault diagnosis (SMFD) of mechanical equipment as a new signal collection and transmission technology, which have attracted a lot of attention recently.
Jianfeng Huang, Guohua Chen, Lei Shu, Qinghua Zhang, Xiaoling Wu   +4 more
doaj   +1 more source