Results 51 to 60 of about 539,809 (286)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Physiographic Features of Faulting in Southern California [PDF]

, 1954
The abundance and variety of faults in southern California provide good opportunity for study of landforms created directly by faulting or indirectly by other processes acting upon faulted materials. High-angle gravity faults, high- and low-angle thrusts,
Sharp, Robert P.
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

An improved glimpse into earthquake activity in northeastern Alaska [PDF]

, 2018
The northeastern Brooks Range is long known to be seismically active, but meaningful analysis of the earthquake activity has been limited by the lack of instrumentation.
Buurman, Helena
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Quaternary activity and seismic hazard of Liangyun fault in northwestern Hubei area

地震科学进展, 2023
The Liangyun fault zone, as one of the largest and most influential faults in the northwestern Hubei area, is located in the uplifted area of Qinling fault block with a length of about 200 km. The structure has a sinistral strike-slip motion with obvious
Min Cui, Rongying Zheng, Jiajing You, Qian Zhao   +3 more
doaj   +1 more source

Acceleration and evolution of faults: An example from the Hunter Mountain-Panamint Valley fault zone, Eastern California [PDF]

, 2011
We present new space geodetic data indicating that the present slip rate on the Hunter Mountain–Panamint Valley fault zone in Eastern California (5.0 ± 0.5 mm/yr) is significantly faster than geologic estimates based on fault total offset and inception ...
Amelung, Falk, Dixon, Timothy H., Gourmelen, Noel, Schmalzle, Gina   +3 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Tectonic structure, evolution, and the nature of oceanic core complexes and their detachment fault zones (13°20′N and 13°30′N, Mid Atlantic Ridge) [PDF]

, 2017
Microbathymetry data, in situ observations, and sampling along the 138200N and 138200N oceanic core complexes (OCCs) reveal mechanisms of detachment fault denudation at the seafloor, links between tectonic extension and mass wasting, and expose the ...
A. Bezos, A. Steinfuhrer, Andreani, B. Ildefonse, B. John, Beltenev, Blackman, Blackman, Blackman, Blackman, Brodsky, Buck, C. Hamelin, C. J. MacLeod, C. Mével, C. Rommevaux, Candela, Candela, Cann, Cannat, Cannat, Cannat, Cherkashev, Collins, Connelly, D. Bonnemains, deMartin, Denny, Dick, Dick, Escartin, Escartín, Escartín, Escartín, Escartín, Escartín, Ferrini, Ferrini, Früh-Green, German, Goff, Hansen, Hayman, Ildefonse, J. A. Olive, J. Escartín, J. Jamieson, John, John, K. Haaga, Karson, L. Triebe, Lavier, Lavier, M. Andreani, M. Cannat, M. Godard, M. Massot-Campos, M. Paquet, M. Rothenbeck, M. Tominaga, MacLeod, MacLeod, MacLeod, Mallows, McCaig, Miranda, Morris, N. Augustin, N. Gracias, Nicosevici, Olive, Ondréas, P. Nomikou, Parnell-Turner, Parnell-Turner, Pertsev, Pertsev, Petersen, R. Campos, R. Garcia, S. Petersen, Schouten, Schroeder, Searle, Searle, Smith, Smith, Smith, Smith, Smith, Spencer, T. Leleu, Tivey, Tucholke, Tucholke, Tucholke, Tucholke, V. Chavagnac, Wilson, Y. Choi, Yeo, Yin, Zhao   +103 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source