Results 61 to 70 of about 29,214 (264)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Geomechanics modeling of ultra-deep fault-controlled carbonate reservoirs and its application in development

Shiyou shiyan dizhi
To enhance the development efficiency of ultra-deep fault-controlled carbonate reservoirs, large-scale rock mechanical experiments were conducted to reveal the deformation and connectivity mechanisms of high-angle to near-vertical fault surfaces.
Zhenzhong CAI, Hui ZHANG, Ke XU, Guoqing YIN, Zhimin WANG, Haiying WANG, Ziwei QIAN, Yu ZHANG   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Response of the stream geomorphic index to fault activity in the Qujiang fault on the southeastern margin of the Qinghai-Xizang Plateau

地震科学进展
Based on 12.5 m resolution ALOS_PALSAR DEM data and hydrology analysis tool in Arcgis10.6, the stream geomorphic indices such as slope, relief degree of the land surface (RDLS), hypsometric integral (HI) and stream length gradient (SL) along the Qujiang ...
Xin Tan, Kuan Liang, Baoqi Ma
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Analysis of Cenozoic Structural Evolution and Basin Formation Models in the Nanpu Sag, Bohai Bay Basin, China

Geosciences
Based on comprehensive interpretation of three-dimensional seismic data and quantitative analysis of basin-boundary fault activity in the Nanpu Sag, this study employs subsidence history backstripping and equilibrium profile techniques to reconstruct the
Liangli Xiong, Han Yu, Junjie Xu, Rongwei Zhu, Zhangshu Lei, Wenbo Du   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Preliminary study on the Late Quaternary activity of important active fault zones along the Yunnan-Tibet railway

地震科学进展
The Yunnan-Tibet railway is located in the southeastern edge of the Tibetan Plateau, where tectonic plates collide and the terrain rapidly changes. Along the line, active faults develops, earthquakes occur frequently, and the intensity of earthquakes is ...
Xianbing Zhang, Hao Yu, Xiao Yu, Changbao Guo, Rui’an Wu, Yang Wang, Ning Zhong   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source