Results 111 to 120 of about 148,579 (316)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

A comparative analysis of fault detection schemes for stochastic continuous-time dynamical systems

open access: yes, 2008
This paper addresses a comparative analysis of the existing schemes for fault detection in continuous-time stochastic dynamical systems. Such schemes prove to be efficient when dealing with specific types of fault functions; on the other hand, they show ...
Zufiria Zatarain, Pedro José
core  

Application of multiple resistive superconducting fault-current limiters for fast fault detection in highly interconnected distribution systems

open access: yes, 2013
Superconducting fault-current limiters (SFCLs) offer several benefits for electrical distribution systems, especially with increasing distributed generation and the requirements for better network reliability and efficiency.
Burt, Graeme   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Achieving Representative Faultloads in Software Fault Injection

open access: yes, 2011
Given the complexity of modern software systems and its pervasiveness in many aspects of our lives, software faults (i.e., bugs) are a dangerous threat.
Natella, Roberto
core  

The walls boundary fault zone and the MØre TrØndelag fault complex:: a case study of two reactivated fault zones. [PDF]

open access: yes, 2001
It is commonly observed that ancient faults or shear zones can become reactivated again and again, either within the same or even superimposed tectonic episodes, yet millions of years apart.
Watts, Lee Mark
core  

Short-circuit fault location method of flexible interconnected distribution network based on waveform similarity

open access: yes电力工程技术
Because of the complex control strategy and weak feed characteristics of soft normal open points (SNOP),traditional fault location methods of distribution networks are no longer applicable to flexible distribution network (FDN).
CHEN Jiming   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Development and interaction of segmented fault systems

open access: yes, 1998
Faults in contractional and extensional settings have been studied, both during fieldwork and from interpretation of 2D and 3D seismic sections. Detailed analysis of the geometries of faults, with displacements of a few mm to 100's m, has provided ...
Kelly, P.G.
core  

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