Results 131 to 140 of about 148,579 (316)

Fault Analysis and Optimization Design of Landing Gear Door Linkage Mechanism

open access: yesNanjing Hangkong Hangtian Daxue Xuebao
To solve the deformation problem of the linkage mechanism in the process of retracting and unwinding the linkage landing gear of the door, according to its motion characteristics, the kinematics and dynamics models of the linkage mechanism are ...
SHI Xurui   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Research on safety methods of airborne embedded software

open access: yesTongxin xuebao, 2015
By analyzed the process of development and running of airborne software with the standards of airworthiness and information security,the factors and threats related with airborne software safety were presented,and the security protected mechanisms based ...
Ya-hui LI, Ya-di ZHANG, Peng GUO
doaj  

Analysis of faults and discussion on operation and maintenance in the Anhui seismic station observation system

open access: yes地震科学进展
To ensure stable operation of Anhui seismic monitoring network, a comprehensive review of the operational status of 31 participating stations from 2020 to 2024 was conducted.
Chao Peng   +8 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Rough set based gas turbine fault isolation study [PDF]

open access: yes, 2010
Gas path fault isolation is one of the key techniques in Engine Health Management systems. In order to accomplish gas path fault isolation successfully for a gas turbine engine, both an accurate off-design performance model and an effective fault ...
Wang, Lihui.
core  

Recent Research Progress in Fault Analysis of Complex Electric Power Systems

open access: yesAdvances in Electrical and Computer Engineering, 2010
In this paper, we adopt a novel approach to the fault analysis of complex electric power systems. Electric power system is one of the most complex artificial systems in the world. Its safe, steady, economical and reliable operating plays a very important
WANG, Z., ZHANG, Y., ZHANG, J., MA, J.
doaj   +1 more source

Fatbox: the fault analysis toolbox

open access: yesSolid Earth
Abstract. Understanding complex fault networks is essential for reconstructing their geological history, quantifying deformation in tectonically active regions, and assessing geohazards and resource potentials. Structure and evolution of fault networks are investigated using a range of methods, including numerical and analogue modelling, as well as the
Pauline Gayrin   +6 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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