Results 141 to 150 of about 148,579 (316)

A generalized fault isolability matrix for improved fault diagnosability analysis

, 2016
A generalized fault isolability matrix is proposed for quantitative analysis of fault isolability properties. The original fault isolability matrix gives information about which faults that are isolable from each other.
Jung, Daniel,, Daniel Jung
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Electrical Motor Current Signal Analysis using a Modulation Signal Bispectrum for the Fault Diagnosis of a Gearbox Downstream

, 2012
Motor current signal analysis has been an effective way for many years of monitoring electrical machines themselves. However, little work has been carried out in using this technique for monitoring their downstream equipment because of difficulties in ...
Gu, Fengshou, Ball, Andrew, Haram, Mansaf, Ball, A. D., Wang, T., Gu, F., Haram, M.   +6 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Structural evolution of the Nam Con Son Basin: quantitative fault analysis applied to a 3-simensional seismic dataset [PDF]

, 2007
The Nam Con Son Basin is one of several Tertiary rift basins located on the continental shelf, offshore Indochina. It has received relatively little attention until recently and remains a poorly understood sedimentary basin.
Pugh, Adam
core  

Bispectrum Analysis of Motor Current Signals for Fault Diagnosis of Reciprocating Compressors

, 2009
The induction motor is the most common driver in industry and has been previously proposed as a means of inferring the condition of an entire equipment train, predominantly through the measurement and processing of power supply parameters.
Gu, Fengshou, Ball, Andrew, Feng Shou Gu, Salem Al-Arbi, Naid, A., Abdelhamid Naid, Yi Min Shao, Naid, Abdelhamid, Al-Arbi, Salem, Shao, Yimin, Andrew Ball   +10 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Structural Analysis of a Vehicle Dynamics Model for Fault Detection and Isolation on the ROboMObil

, 2013
The ROboMObil, a mobility prototype under development at the DLR, differs from most current road vehicles with its high degree of overactuation with regards to the vehicle dynamics.
Lok Man Ho, Ho, Lok Man
core   +1 more source