Results 131 to 140 of about 12,263,286 (349)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A New Criterion for Transformer Excitation Inrush Current Identification Based on the Wasserstein Distance Algorithm

Energies
To circumvent the computational bottlenecks associated with the intermediate steps (e.g., least squares fitting) in conventional sine wave similarity principles and directly acquire the energy metrics required for stabilized sinusoidal waveform ...
Shanshan Zhou, Jingguang Huang, Yuanning Zhang, Yulong Li   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Superconducting Fault Current Limiter

, 2018
The superconducting fault current limiter concept explains two types of superconducting materials firstly resistive SFCL, Secondly, Inductive-SFCL. We also study some applications of SFCLs which is used to limit the fault - current that occurs in power system.
openaire   +2 more sources

Real-time fault diagnosis for propulsion systems [PDF]

Current research toward real time fault diagnosis for propulsion systems at NASA-Lewis is described. The research is being applied to both air breathing and rocket propulsion systems.
Delaat, John C., Duyar, Ahmet, Guo, Ten-Huei, Merrill, Walter C.   +3 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Asymmetrical Fault Current Calculation Method and Influencing Factors Analysis of Droop-Controlled Inverters

CSEE Journal of Power and Energy Systems
Since the fault dynamic of droop-controlled inverter is different from synchronous generators (SGs), protection devices may become invalid, and the fault overcurrent may damage power electronic devices and threaten the safety of the microgrid. Therefore,
Huimin Zhao, Zhikang Shuai, Jun Ge, An Luo, Weimin Wu, Z. John Shen   +5 more
doaj   +1 more source

Age constraints for the present fault configuration in the Imperial Valley, California: Evidence for northwestward propagation of the Gulf of California rift system [PDF]

Releveling and other geophysical data for the Imperial Valley of southern California suggest the northern section of the Imperial-Brawley fault system, which includes the Mesquite Basin and Brawley Seismic Zone, is much younger than the 4 to 5 million ...
Larsen, Shawn, Reilinger, Robert
core   +1 more source