Results 81 to 90 of about 7,855,293 (193)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Fault ride-through enhancement of fixed speed wind turbine using bridge-type fault current limiter
Journal of Electrical Systems and Information Technology, 2016 The interaction between wind energy turbines and the grid results in two main problems, increasing the short-circuit level and reducing the Fault Ride-Through (FRT) capability during faults.
Mostafa I. Marei +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Alexandria Engineering Journal, 2015 This paper addresses the problem of overcurrent relays (OCRs) coordination in the presence of DGs. OCRs are optimally set to work in a coordinated manner to isolate faults with minimal impacts on customers.
A. Elmitwally, E. Gouda, S. Eladawy
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Research Status and Perspective of Fault Current Limiter
Kongzhi Yu Xinxi Jishu, 2011 It summarizes the theory and categories of fault current limiter (FCL) as well as its key technologies, describes the research status and products of FCL both in China and abroad. Technical requirements of FCL in urban grid application are analyzed, upon
谢炜, 李欣, 戴朝波
doaj
Design Aspects and Test of an Inductive Fault Current Limiter
Electrical, Control and Communication Engineering, 2014 Magnetic shielding inductive fault current limiters with high temperature superconducting tapes are considered as emerging devices that provide technology for the advent of modern power grids. The development of such limiters requires magnetic iron cores
Arsénio Pedro +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source