Results 71 to 80 of about 7,553,652 (285)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Fault current limiter of VSC-HVDC systems using variable resistive bridge controller

, 2021
This paper proposes a fuzzy logic controller (FLC) based variable resistive bridge type fault current limiter (VR-BFCL) to minimize the impact of faults on voltage source converter high voltage direct current (VSC-HVDC) systems.
AL-Ismail, FS, Md. Shafiul Alam, Md Alamgir Hossain, Fahad Saleh AL-Ismail, Alam, MS, M.A. Abido, Hossain, MA, Abido, MA   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Review of DC Fault Current Limiters for HVDC Systems: Classification and Design Considerations of Non-Superconducting Topologies

IEEE Open Journal of Power Electronics
The rapid expansion of voltage source converter-based high voltage DC grids has made DC fault protection a critical research priority, due to low network impedance and the absence of natural current zero crossings.
Mohammad Soltani Mohammadi, Saeed Norouztamar, Hossein Iman-Eini, Mohammad Hamed Samimi, Marco Liserre   +4 more
doaj   +1 more source

Fault Current Limiter Controller for the Protection of Inverter Based Distributed Generation

, 2020
Power systems are becoming more vulnerable to different faults due to high current. This threat is increasing day by day due to the shift of power system from conventional generation to power electronic-based distributed generation.
Islam, MA, Rahman, A, Alam, MS, Al-Ismail, FS, Hossain, MA   +4 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Quenched Flux-Coupling Superconducting Fault Current Limiter Scheme and Its Electromagnetic Design Method. [PDF]

Materials (Basel), 2023
Yan S, Ren L, Zhao J, Xu Y, Shen S, Xiong Y, Liu B, Xiao F.   +7 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Combining finite element and reinforcement learning methods to design superconducting coils of saturated iron-core superconducting fault current limiter in the DC power system. [PDF]

PLoS One, 2023
Kim CS, Dao VQ, Park J, Jang B, Lee SJ, Park M.   +5 more
europepmc   +1 more source