Results 81 to 90 of about 7,553,652 (285)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A voltage-clamped bidirectional fault current limiter based on a three-winding coupled inductor for DC power grids

International Journal of Electrical Power & Energy Systems
The DC fault is a serious challenge to voltage-source-converter-based HVDC (VSC-HVDC) systems, and the fault current limiter (FCL) is one of the key measures to solve the DC fault and reduce the capacity of the DC circuit breaker.
Ziao Yuan, Siyuan Liu, Jinchao Chen, Zhiyuan Liu, Yingsan Geng   +4 more
doaj   +1 more source

Design of a multifunction novel flexible fault current limiter for AC distribution network. [PDF]

PLoS One, 2021
Liu Y, Guan L, Tan Z, Yang K, Guo F, Chen Y, Liu R, Zheng F.   +7 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Novel Topology of DC Energy-Released Circuit For Saturated-Core Fault Current Limiter

IEEE Access, 2019
The saturated-core fault current limiter (SCFCL) has been studied by several scholars in the past decades. However, these studies have mainly focused on the AC coils of the SCFCL, the DC excitation has seldom been mentioned. In this paper, the DC coil of
Haocong Shen, Fei Mei, Hongfei Chen, Jianyong Zheng   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Analisa Penggunaan Superconducting Fault Current Limiter (SFCL) Untuk Melindungi Peralatan di PT Pindo Deli

Jurnal Teknik ITS, 2015
Increas demand load and power capacity requirement at PT Pindo Deli then the short circuit current that occur will be greater. this can cause damage to electrical equipment located around the point of interrupting and resulting failure of the electrical ...
Yohanes Sabriant Widyo Utomo, Margo Pujiantara, Arif Musthofa   +1 more
doaj  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Improved Low Voltage Ride-Through Capability of DFIG with ESO Controller under Unbalanced Network Conditions

Majlesi Journal of Electrical Engineering
Under unbalanced grid condition, in a Doubly-Fed Induction Generator (DFIG), voltage, current, and flux of the stator become asymmetric. Therefore, active-reactive power and torque will be oscillating.
Ali Akbar Vali, Seyed Mohammad Hassan Hosseni, Javad Olamaei   +2 more
doaj   +1 more source