Results 91 to 100 of about 6,041 (302)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

A novel time domain protection technique for multi-terminal HVDC networks utilising travelling wave energy [PDF]

, 2018
Fault vulnerability and protection issues are major challenge in realising multi-terminal HVDC transmission system, also termed HVDC grids. This paper presents a novel time domain and transient based protection technique for application to HVDC grids ...
Adamczyk, Andrzej, Griffiths, Alison, Ha, Hengxu, Ikhide, Monday, Subramanian, Sankara, Tennakoon, Sarath   +5 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Multifaceted Functionalities of Bridge-Type DC Reactor Fault Current Limiters: An Experimentally Validated Investigation

Energies
With the ongoing expansion and interconnection of electrical power systems, alongside the rapid proliferation of renewable distributed generations (DGs), the short-circuit extent in the power grid is experiencing a significant rise.
Behzad Behdani, Ali Moghim, Sheyda Mousavi, Mostafa Soltanfar, Mojgan Hojabri   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Study on Recovery Time of Conduction-Cooled Resistive Superconducting Fault Current Limiter

Energies
This paper presents the influence of superconducting tape insulation on the recovery time of superconducting fault current limiters. The analysis is based on the experimental results of short-circuit tests.
Janusz Kozak
doaj   +1 more source

Fault Ride-through Capability Enhancement of Voltage Source Converter-High Voltage Direct Current Systems with Bridge Type Fault Current Limiters

Energies, 2017
This paper proposes the use of bridge type fault current limiters (BFCLs) as a potential solution to reduce the impact of fault disturbance on voltage source converter-based high voltage DC (VSC-HVDC) systems.
Md Shafiul Alam, Mohammad Ali Yousef Abido   +1 more
doaj   +1 more source

Distributed voltage control in electrical power systems [PDF]

, 2009
Voltage instability stems from the attempt of load dynamics to restore power consumption beyond the capability of the combined transmission and generation system.
Boel, René, Moradzadeh, Mohammad
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Effects of high pressure on the physical properties of MgB2

, 2010
The synthesis of MgB2-based materials under high pressure gave the possibility to suppress the evaporation of magnesium and to obtain near theoretically dense nanograined structures with high superconducting, thermal conducting, and mechanical ...
Danilenko, N., Dellith, J., Dub, S., Eisterer, M., Fesenko, I., Gawalek, W., Goldacker, W., Habisreuther, T., Karau, F., Kozyrev, A., Litzkendorf, D., Meerovich, V., Moshchil, V., Nagorny, P., Noudem, J., Prikhna, T., Rindfleisch, M., Savchuk, Ya., Schmidt, Ch., Serga, M., Sergienko, N., Sokolovsky, V., Soldatov, A., Sverdun, V., Tkach, V., Tompsic, M., Turkevich, V., Weber, H. W., Wendt, M., You, S.   +29 more
core   +1 more source