Results 81 to 90 of about 6,041 (302)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Evaluating the impact of superconducting fault current limiters on distribution network protection schemes [PDF]

, 2011
Rising fault levels are becoming increasingly problematic in the UK distribution network, with large sections of the network operating near to its designed fault level capability.
Abdulhadi, Ibrahim, Burt, Graeme M, Emhemed, Abdullah, Kincaid, Jennifer   +3 more
core  

A transient and non-unit-based protection technique for DC grids based on the rate-of-change (R-o-C) of the fault induced travelling wave components [PDF]

, 2019
This paper presents a transient and non-unit-based protection scheme for consideration in DC grids of the future. The technique utilises the rate-of-change (R-o-C) of the associated travelling wave components following the occurrence of a fault to ...
Azizi, Barker, Chamia, Christopoulos, Crossley, Davidson, Dong, Dong, Dong, Ha, Hao, Hertem, Ikhide, Jiang, Johns, Liu, Liu, Naidoo, Saleh, Shehab-Eldin, Sneath, Wang, Xiaolei, Yan, Ying   +24 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Computation of Losses in HTS Under the Action of Varying Magnetic Fields and Currents

, 2013
Numerical modeling of superconductors is widely recognized as a powerful tool for interpreting experimental results, understanding physical mechanisms and predicting the performance of high-temperature superconductor (HTS) tapes, wires and devices.
Grilli, Francesco, Gömöry, Fedor, Nguyen, Doan N., Pardo, Enric, Stenvall, Antti, Yuan, Weijia   +5 more
core   +1 more source

Fault management strategies and architecture design for turboelectric distributed propulsion [PDF]

, 2016
The TeDP concept has been presented as a possible solution to reduce aircraft emissions despite the continuing trend for increased air traffic. However, much of the benefit of this concept hinges on the reliable transfer of electrical power from the ...
Flynn, M.-C., Galloway, S.J., Jones, C.E., Norman, P.J.   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Comparison of resistive and inductive superconductor fault current limiters in AC and DC micro-grids

AIMS Energy, 2020
Superconducting Fault Current Limiters (SFCL) have been used in power systems for many years, however the best possible positioning of different SFCL still needs a lot of work. Resistive and Inductive are two types of SFCL used in power system.
Arqum Shahid, Ahsan Ali, Faheem Ashiq, Umer Amir Khan, Muhammad Ilyas Menhas , Sajjad Manzoor   +5 more
doaj   +1 more source

Behavior Of Superconducting Fault Current Limiter Under Fault Condition

, 2017
Now a days due to increase in electricity demand for the purpose of industrialization, agriculture, domestic and educational etc there exists more chances of fault occurance. The Faults occurs due to insulation damaging, breaking of conductor, short circuit, lightning etc.
KARUNA L. BARI, S. M. SHEMBEKAR
openaire   +1 more source

Resistive DC fault current limiter

The Journal of Engineering, 2017
The DC fault current of bipolar short‐circuit fault rises rapidly due to the low damping performance of the modular multilevel converter‐high‐voltage DC (MMC‐HVDC) system. It is of great engineering significance to study the DC fault current limiter (FCL) in HVDC systems for suppressing the DC fault current, resulting in making the DC circuit breaker ...
Xie Sujuan, Qiu Yufeng, Bi Tianshu
openaire   +1 more source