Results 101 to 110 of about 5,249,936 (356)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Software-implemented fault insertion: An FTMP example [PDF]

open access: yes
This report presents a model for fault insertion through software; describes its implementation on a fault-tolerant computer, FTMP; presents a summary of fault detection, identification, and reconfiguration data collected with software-implemented fault ...
Czeck, Edward W.   +2 more
core   +1 more source

Software fault characteristics: A synthesis of the literature [PDF]

open access: yes, 2015
Faults continue to be a significant problem in software. Understanding the nature of these faults is important for practitioners and researchers. There are many published fault characteristics schemes but no one scheme dominates.
Bowes, D   +4 more
core  

Classifying the Correctness of Generated White-Box Tests: An Exploratory Study

open access: yes, 2017
White-box test generator tools rely only on the code under test to select test inputs, and capture the implementation's output as assertions. If there is a fault in the implementation, it could get encoded in the generated tests. Tool evaluations usually
Honfi, David, Micskei, Zoltan
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

An Improved LightGBM Algorithm for Online Fault Detection of Wind Turbine Gearboxes

open access: yesEnergies, 2020
It is widely accepted that conventional boost algorithms are of low efficiency and accuracy in dealing with big data collected from wind turbine operations.
Mingzhu Tang   +6 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Fault Detection and Health Monitoring Scheme for Ship Propulsion Systems Using SVM Technique

open access: yesIEEE Access, 2018
Both the model-based and data-driven techniques for fault detection have their merits and drawbacks. The fault detection systems are usually laid out separately with the health monitoring systems in practice.
Jing Zhou   +4 more
doaj   +1 more source

Robust fault detection filter design for a class of discrete‐time conic‐type non‐linear Markov jump systems with jump fault signals

open access: yesIET Control Theory & Applications, 2020
This study investigates the robust fault detection filter design problem for a class of discrete-time conic-type nonlinear Markov jump systems with jump fault signals.
Xuefei Dong, Shuping He, V. Stojanovic
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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