Results 111 to 120 of about 3,067 (278)

GPS Vector Tracking Loop with Fault Detection and Exclusion

Computers, Materials & Continua, 2021
Dah-Jing Jwo, Meng-Hsien Hsieh
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

A Weighted Grid for Measuring Program Robustness [PDF]

, 2012
Robustness is a key issue for all the programs, especially safety critical ones. In the literature, Program Robustness is defined as “the degree to which a system or component can function correctly in the presence of invalid input or stressful ...
ABDALLAH, MOHAMMAD,MAHMOUD,AREF
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

GNSS Integrity Enhancement for Urban Transport Applications by Error Characterization and Fault Detection and Exclusion (FDE)

, 2018
Géolocalisation et Navigation dans l'Espace et le Temps, Journées Scientifiques 2018 de l'URSI, Paris, France, 28-/03/2018 - 29/03/2018Au cours des dernières décennies, de plus en plus d'applications de transport urbain basées sur les systèmes de ...
ZHU, Ni, Berbineau, Marion, MARAIS, Juliette, Betaille, David   +3 more
core   +1 more source

Complex Dynamics and Intelligent Control: Advances, Challenges, and Applications in Mining and Industrial Processes

Mathematics
Complex dynamics and nonlinear systems play a critical role in industrial processes, where complex interactions, high uncertainty, and external disturbances can significantly impact efficiency, stability, and safety.
Luis Rojas, Víctor Yepes, José Garcia
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Evaluating ML-Based Anomaly Detection on Unified OpenTelemetry Telemetry: An Empirical Study Across Traces, Metrics, and Logs

IEEE Access
To our knowledge, no empirical study has evaluated machine learning anomaly detection across all three OpenTelemetry (OTel) signal types together. We benchmark eight semi-supervised models on 51 GB of OTel telemetry from two microservice testbeds (400 ...
Mateen Ali Anjum
doaj   +1 more source