Results 41 to 50 of about 252,496 (356)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Fault location and isolation technology for power grid automation based on intelligent algorithms

Energy Informatics
Background Power grid automation is critical for maintaining the stability and reliability of electrical grids. A major challenge in power grid management is identifying and isolating faults quickly and accurately to avoid widespread disruptions ...
Qi Guo, Fuhe Wang, Suxia Cheng, Ke Wang, Yifan Zhang   +4 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Fault Detection and Isolation for Redundant Inertial Measurement Unit under Quantization

Applied Sciences, 2018
Fault detection and isolation with redundant strapdown inertial measurement unit is critical for ensuring the reliability of the guidance or navigation system in the fields of both aeronautics and astronautics.
Tong Zhang, Fenfen Wang, Wenxing Fu
doaj   +1 more source

Model-based fault detection and isolation for wind turbine [PDF]

, 2012
In this paper, a quantitative model based method is proposed for early fault detection and diagnosis of wind turbines. The method is based on designing an observer using a model of the system. The observer innovation signal is monitored to detect faults.
Hwas, Abdulhamed Moh Suliman, Katebi, Reza   +1 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A Hierarchical Decision Fusion Diagnosis Method for Rolling Bearings

Applied Sciences, 2021
In order to achieve accurate fault diagnosis of rolling bearings, a hierarchical decision fusion diagnosis method for rolling bearings is proposed. The hierarchical back propagation neural networks (BPNNs) architecture includes a fault detection layer ...
Jingzhou Fei, Xinran Lv, Yunpeng Cao, Shuying Li   +3 more
doaj   +1 more source

Comparison of different classification algorithms for fault detection and fault isolation in complex systems [PDF]

, 2018
Due to the lack of sufficient results seen in literature, feature extraction and classification methods of hydraulic systems appears to be somewhat challenging.
Jung, Marcel, Niculita, Octavian, Skaf, Zakwan   +2 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source