Results 51 to 60 of about 1,108,433 (294)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Real-time fault diagnosis and fault-tolerant control [PDF]

, 2015
This "Special Section on Real-Time Fault Diagnosis and Fault-Tolerant Control" of the IEEE Transactions on Industrial Electronics is motivated to provide a forum for academic and industrial communities to report recent theoretic/application results in ...
Cecati, Carlo, Ding, Steven X., Gao, Zhiwei   +2 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

HYBRID DEEP FAULT DETECTION AND ISOLATION: COMBINING DEEP NEURAL NETWORKS AND SYSTEM PERFORMANCE MODELS

International Journal of Prognostics and Health Management, 2019
With the increased availability of condition monitoring data on the one hand and the increased complexity of explicit system physics-based models on the other hand, the application of data-driven approaches for fault detection and isolation has recently ...
Manuel Arias Chao, Chetan Kulkarni, Kai Goebel, Olga Fink   +3 more
doaj   +1 more source

A Bayesian Approach to Fault Identification in the Presence of Multi-component Degradation

International Journal of Prognostics and Health Management, 2017
Fault diagnosis typically consists of fault detection, isolation and identification. Fault detection and isolation determine the presence of a fault in a system and the location of the fault.
Yufei Lin, Skaf Zakwan, Ian Jennions
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Solid-State Circuit Breaker Topology Design Methodology for Smart DC Distribution Grids with Millisecond-Level Self-Healing Capability

Energies
To address the challenges of prolonged current isolation times and high dependency on varistors in traditional flexible short-circuit fault isolation schemes for DC systems, this paper proposes a rapid fault isolation circuit design based on an adaptive ...
Baoquan Wei, Haoxiang Xiao, Hong Liu, Dongyu Li, Fangming Deng, Benren Pan, Zewen Li   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Fault detection and isolation of actuator failures for a large transport aircraft [PDF]

, 2007
- We consider the problem of designing residual generators with least dynamical orders to solve actuator fault detection and isolation problems for a Boeing 747-100/200 aircraft. The main result of our analysis is the proof of feasibility of the complete
Varga, Andreas
core  

A New Fault Simulation Test and Evaluation Method of Distribution Automation System

MATEC Web of Conferences, 2016
This paper proposes a fault simulation test method suitable for five divisions of power supply area. Distribution network structures are classified according to different power supply areas and more active interference is injected into test cases, which ...
Fan Wenbo, An Yu, Liu Dong, Guan Shilei
doaj   +2 more sources