Results 51 to 60 of about 252,496 (356)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The Soviet Viewpoint on Nuclear Weapons in International Law [PDF]

, 1964
A flexible, model based fault detection and isolation (FDI) system for an arbitrary configuration of a water tank world has been designed and implemented in MATLAB, SIMULINK and dSPACE.
Bergman, Nicklas, Larsson, Magnus
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

HYBRID DEEP FAULT DETECTION AND ISOLATION: COMBINING DEEP NEURAL NETWORKS AND SYSTEM PERFORMANCE MODELS

International Journal of Prognostics and Health Management, 2019
With the increased availability of condition monitoring data on the one hand and the increased complexity of explicit system physics-based models on the other hand, the application of data-driven approaches for fault detection and isolation has recently ...
Manuel Arias Chao, Chetan Kulkarni, Kai Goebel, Olga Fink   +3 more
doaj   +1 more source

Fault detection and isolation for a wind turbine benchmark using a mixed Bayesian/Set-membership approach [PDF]

, 2015
This paper addresses the problem of fault detection and isolation of wind turbines using a mixed Bayesian/Set-membership approach. Modeling errors are assumed to be unknown but bounded, following the set-membership approach.
Blesa, Joaquim, Fernández Cantí, Rosa M., Puig, Vicenç, Tornil-Sin, Sebastian   +3 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Solid-State Circuit Breaker Topology Design Methodology for Smart DC Distribution Grids with Millisecond-Level Self-Healing Capability

Energies
To address the challenges of prolonged current isolation times and high dependency on varistors in traditional flexible short-circuit fault isolation schemes for DC systems, this paper proposes a rapid fault isolation circuit design based on an adaptive ...
Baoquan Wei, Haoxiang Xiao, Hong Liu, Dongyu Li, Fangming Deng, Benren Pan, Zewen Li   +6 more
doaj   +1 more source

A Bayesian Approach to Fault Identification in the Presence of Multi-component Degradation

International Journal of Prognostics and Health Management, 2017
Fault diagnosis typically consists of fault detection, isolation and identification. Fault detection and isolation determine the presence of a fault in a system and the location of the fault.
Yufei Lin, Skaf Zakwan, Ian Jennions
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A New Fault Simulation Test and Evaluation Method of Distribution Automation System

MATEC Web of Conferences, 2016
This paper proposes a fault simulation test method suitable for five divisions of power supply area. Distribution network structures are classified according to different power supply areas and more active interference is injected into test cases, which ...
Fan Wenbo, An Yu, Liu Dong, Guan Shilei
doaj   +2 more sources