Results 81 to 90 of about 1,108,433 (294)

Model-Based Fault Detection & Control Design Applied to a Pneumatic Application [PDF]

, 2010
In safety critical applications it is important to detect faults that may compromise system safety and to take appropriate action. This paper discusses research carried-out on the development and validation of a model-based fault detection and isolation (
Goodall, R., Dixon, R., Pearson, John, John Pearson (1255110), R. Dixon, R. Goodall, Roger Goodall (1250520), Roger Dixon (1259193), Dixon, R.; id_orcid, Grewal, Karmjit Singh, K.S. Grewal, J. Pearson, Pearson, J., Grewal, K. S., Karmjit Singh Grewal (7202081), Goodall, Roger M.   +15 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

On parametric solution of fault detection problems [PDF]

, 2011
We discuss the solution of the fault detection problem in presence of parametric uncertainties. The basic approach is an extension of the nullspace method for constant systems to the case of linear parameter varying (LPV) models.
Andras Varga, Varga, A.
core   +1 more source

Multiple-Actuator Fault Isolation Using a Minimal ℓ₁-Norm Solution with Applications in Overactuated Electric Vehicles. [PDF]

Sensors (Basel), 2022
Park J, Park Y.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Robust Fault Detection of Switched Linear Systems with State Delays [PDF]

, 2009
This correspondence deals with the problem of robust fault detection for discrete-time switched systems with state delays under an arbitrary switching signal.
Shi, Peng, Wang, W, Wang, Dong, Wang, Wei, Wang, D., Wang, W., Wang, D, Shi, P.   +7 more
core   +1 more source

An Improved Test Selection Optimization Model Based on Fault Ambiguity Group Isolation and Chaotic Discrete PSO

Complexity, 2018
Sensor data-based test selection optimization is the basis for designing a test work, which ensures that the system is tested under the constraint of the conventional indexes such as fault detection rate (FDR) and fault isolation rate (FIR).
Xiaofeng Lv, Deyun Zhou, Yongchuan Tang, Ling Ma   +3 more
doaj   +1 more source

A Comprehensive Case Study of Data-Driven Methods for Robust Aircraft Sensor Fault Isolation. [PDF]

Sensors (Basel), 2021
Cartocci N, Napolitano MR, Costante G, Fravolini ML.   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

On computing least order fault detectors using rational nullspace bases [PDF]

, 2003
We propose a numerically reliable computational approach to design least order fault detectors using descriptor system techniques. This approach is based on a new numerically stable algorithm to compute least order rational nullspace bases of rational ...
A. Varga, Varga, Andras
core   +1 more source