Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Multi-Source Partial Discharge Fault Location with Comprehensive Arrival Time Difference Extraction Method and Multi-Data Dynamic Weighting Algorithm. [PDF]
Entropy (Basel), 2023 Wang D, Du L, Wang T, Zhao X.
europepmc +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Fault severity diagnosis of rolling element bearings based on kurtogram and envelope analysis [PDF]
, 2014 Faults in rolling element bearing are among the main causes of breakdown in rotating machines. Vibration is an effective technique for machine condition monitoring.
Gu, Fengshou +6 more
core +1 more source
Machine Learning-Based Fault Location for Smart Distribution Networks Equipped with Micro-PMU. [PDF]
Sensors (Basel), 2022 Mirshekali H +3 more
europepmc +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
The fault detection and severity diagnosis of rolling element bearings using modulation signal bispectrum [PDF]
The rolling element bearing is a key part in many mechanical equipment. The accurate and timely diagnosis of its faults is critcal for predictive maintenance. Vibration signals from a defective bearing with a localized fault contain a series of impulsive
Gu, Fengshou +3 more
core +3 more sources
Fault location method for multi-section hybrid lines considers velocity uncertainty
International Journal of Electrical Power & Energy SystemsFault location accuracy of traveling wave method is constrained to the reliable traveling wave velocity. In this paper, a novel fault traveling waves location method is proposed to eliminate the effects of velocity uncertainty on hybrid lines’ fault ...
Liwei Xie +5 more
doaj +1 more source
Random Forest Regressor-Based Approach for Detecting Fault Location and Duration in Power Systems. [PDF]
Sensors (Basel), 2022 El Mrabet Z +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source