Results 61 to 70 of about 35,036 (317)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Geological modeling of carbonate fracture-cavity reservoir: case study of Shunbei fault zone No. 5
Frontiers in Earth ScienceIn the Shunbei area of the Tarim Basin, China, carbonate fault-controlled fracture-cavity reservoirs exhibit complex internal structures and complex heterogeneity, with primary reservoir spaces including fault plane, cave-like, and disordered body ...
Bolin Li +4 more
doaj +1 more source
Current–time characteristics of resistive superconducting fault current limiters
, 2012 Superconducting fault current limiters (SFCLs) may play an important role in power-dense electrical systems. Therefore, it is important to understand the dynamic characteristics of SFCLs.
Burt, Graeme +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
3D geological fine modeling and dynamic updating method of fault slope in open-pit coal mine
Scientific ReportsCombining the requirements for refined modeling and dynamic update of fault slope geological models in open-pit coal mines, we systematically elaborated on the elements and rules of slope 3D geological modeling and proposed a fine modeling and dynamic ...
Jie Yuan, Guangwei Liu, Senlin Chai
doaj +1 more source
A Research on the Electrical Test Fault Diagnostic and Data Mining of a Manned Spacecraft
MATEC Web of Conferences, 2017 The paper introduces the modeling method and modeling tool for the fault diagnosis of manned spacecraft, the multi-signal flow graph model of a manned space equipment was established using this method; the framework of the fault detection and diagnosis ...
Yang Feng, Lv Ye, Li Wenting
doaj +1 more source
J. Univers. Comput. Sci., 1999 JUCS - Journal of Universal Computer Science Volume Nr.
openaire +3 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
DIAGNOSIS WITH A FUNCTION-FAULT MODEL
Applied Artificial Intelligence, 1989 This paper introduces a domain model for use in diagnostic problem solving. It emphasizes functional decomposition, rather than behavior, cause-effect, or spatial structure, and represents explicitly the faults of a system together with its possible explanations.
openaire +2 more sources