Results 61 to 70 of about 23,612 (232)

Fold-Related Faults Track Progressive Fold Development from Layer-Parallel Shortening to Subsequent Orthogonal Extension within an Appalachian Buckle Fold System: Bear Valley Mine, Shamokin, PA, USA [PDF]

Lithosphere
Outstanding three-dimensional exposures of adjacent folds in an abandoned coal mine within the Appalachian Valley-and-Ridge tectonic province permit a detailed analysis of macroscopic strain accommodation by minor faulting in the lead up to and during ...
Arlo Brandon Weil, Mary Beth Gray, Kylie G. Cush, Mattathias D. Needle, Juliet G. Crider   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Deep structural setting of the North American-Caribbean plate boundary in eastern Guatemala [PDF]

Geofísica Internacional, 2009
Two-dimensional inverse gravity modeling is presented to help determine the deep structural framework of the left-lateral Polochic-Motagua fault systems. They represent a major segment of the North American-Caribbean plate boundary.
G. Giunta, M. Guzmán-Speziale, M. Menichetti, E. Lodolo, C. Zanolla   +4 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Kolmogorov–Arnold Network in the Fault Diagnosis of Oil-Immersed Power Transformers

Sensors
Instabilities in energy supply caused by equipment failures, particularly in power transformers, can significantly impact efficiency and lead to shutdowns, which can affect the population.
Thales W. Cabral, Felippe V. Gomes, Eduardo R. de Lima, José C. S. S. Filho, Luís G. P. Meloni   +4 more
doaj   +1 more source

Relationship between tectonic structures and hydrogeochemical compartmentalization in aquifers: Example of the “Jeffara de Medenine” system, south–east Tunisia

Journal of Hydrology: Regional Studies, 2015
Study region: “Jeffara de Medenine” aquifer system in south-eastern Tunisia. Study focus: This study investigates the role of fault structures in the distribution of hydrogeochemical facies and groundwater compartmentalization for the aquifer system. New
Hayet Chihi, Ghislain de Marsily, Habib Belayouni, Houcine Yahyaoui   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source