Results 101 to 110 of about 239,815 (291)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Software fault characteristics: A synthesis of the literature [PDF]

open access: yes, 2015
Faults continue to be a significant problem in software. Understanding the nature of these faults is important for practitioners and researchers. There are many published fault characteristics schemes but no one scheme dominates.
Bowes, D   +4 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Research on fault time prediction method for high speed rail BTM unit based on multi method interactive validation

open access: yesHigh-Speed Railway
The Balise Transmission Module (BTM) unit of the on-board train control system is a crucial component. Due to its unique installation position and complex environment, this unit has a higher fault rate within the on-board train control system. To conduct
Limin Fu   +4 more
doaj   +1 more source

FPA-FL: Incorporating Static Fault-proneness Analysis into Statistical Fault Localization

open access: yes, 2017
Despite the proven applicability of the statistical methods in automatic fault localization, these approaches are biased by data collected from different executions of the program.
Feyzi, Farid, Parsa, Saeed
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Predicting Phishing Websites using Neural Network trained with Back-Propagation [PDF]

open access: yes, 2013
Phishing is increasing dramatically with the development of modern technologies and the global worldwide computer networks. This results in the loss of customer’s confidence in e-commerce and online banking, financial damages, and identity theft ...
McCluskey, T.L.   +2 more
core  

EFFECTIVENESS OF FAULT PREDICTION

open access: yes, 2018
The research community in software engineering is trying to find a way on how to achieve the goal of having a fault-free software. The industry that will use a near fault-free software will have it easier to lower the costs of maintenance and the versions of delivered software will be more qualitative.
openaire   +2 more sources

Fault prediction in distributed systems gone wild

open access: yesProceedings of the 4th International Workshop on Large Scale Distributed Systems and Middleware, 2010
We consider the problem of predicting faults in deployed, large-scale distributed systems that are heterogeneous and federated. Motivated by the importance of ensuring reliability of the services these systems provide, we argue that the key step in making these systems reliable is the need to automatically predict faults. For example, doing so is vital
Canini, Marco   +3 more
openaire   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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