Results 41 to 50 of about 16,975 (265)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Data Super-Network Fault Prediction Model and Maintenance Strategy for Mechanical Product Based on Digital Twin

IEEE Access, 2019
When mechanical products work in complex environments, it is imperative to build an optimal maintenance strategy, based on accurate positioning of fault locations and prediction of fault conditions.
Zhifeng Liu, Wei Chen, Caixia Zhang, Congbin Yang, Hongyan Chu   +4 more
doaj   +1 more source

Achieving Reliability in Cloud Computing by a Novel Hybrid Approach

Sensors, 2023
Cloud computing (CC) benefits and opportunities are among the fastest growing technologies in the computer industry. Cloud computing’s challenges include resource allocation, security, quality of service, availability, privacy, data management ...
Muhammad Asim Shahid, Muhammad Mansoor Alam, Mazliham Mohd Su’ud   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Prediction of power grid fault repair time based on multi-model fusion

Dianxin kexue, 2020
There are many types of power grid faults,and the reasons are complicated.The prediction of fault repair time is difficult.Due to the rise of new technologies such as deep learning,it is feasible to accurately mine the faulty worksheet and accurately ...
Jianyue PAN, Yizhen WU, Hanlin XU
doaj   +2 more sources

Fault Prediction of Double Toothed Roller Crusher Failure in Open Pit Mines Based on Digital Twinning Technique of ASL-CatBoost Algorithm

IEEE Access
The bearings of double toothed roller crushers in open pit mines are prone to failure during prolonged operation, resulting in reduced productivity and shortened equipment life.
Pubo Gao, Sihai Zhao
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PT-Informer: A Deep Learning Framework for Nuclear Steam Turbine Fault Diagnosis and Prediction

Machines, 2023
The health status of equipment is of paramount importance during the operation of nuclear power plants. The occurrence of faults not only leads to significant economic losses but also poses risks of casualties and even major accidents, with unimaginable ...
Jiajing Zhou, Zhao An, Zhile Yang, Yanhui Zhang, Huanlin Chen, Weihua Chen, Yalin Luo, Yuanjun Guo   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source