Results 71 to 80 of about 445,363 (308)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Fault section location of collector lines based on phase comparison of zero-sequence current using the Kaiser window

International Journal of Electrical Power & Energy Systems
To address the limitations of existing single-phase grounding fault location methods for collector lines in wind farms, especially their insufficient adaptability to multi-branch topologies, this paper proposes a fault section location method based on ...
Yue Dai, Hongchun Shu, Cheng Guan, Yutao Tang, Yiming Han   +4 more
doaj   +1 more source

An Object-Based Approach to Modelling and Analysis of Failure Properties [PDF]

, 1997
In protection systems, when traditional technology is replaced by software, the functionality and complexity of the system is likely to increase. The quantitative evidence normally provided for safety certification of traditional systems cannot be relied
Cepin, M., de Lemos, Rogério, Mavko, B., Riddle, S., Saeed, Amer   +4 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Research on primary frequency regulation and VSC-HVDC frequency synchronization control coordination method for large-scale hydropower DC export regional grid

International Journal of Electrical Power & Energy Systems
In asynchronous grid connection mode, the rotational inertia of the partitioned synchronized grid decreases, leading to prominent frequency stability issues.
Hongchun Shu, Huaibin Gao, Zongxue Shao, Yongzan Cui, Wei Zhao   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Analysis of multiple lightning overvoltage on 110 kV transmission lines

Results in Engineering
As pointed out by the CIGRE TB 549 report issued by the International Power Grid Committee, >80 % of cloud-to-ground lightning are multiple lightning strokes (MLS), posing a severe threat to overhead transmission lines.
Yutao Tang, Haoming Liu, Hongchun Shu, Yue Dai, Yiming Han   +4 more
doaj   +1 more source

Validation of fast and selective protection scheme for an LVDC distribution network [PDF]

, 2016
Low Voltage Direct Current (LVDC) distribution systems are one of the emerging technologies to recently attract attention for more efficient use of energy, and wider uptake of distributed renewables and energy storage. They do however present significant
Burt, Graeme M., Emhemed, Abdullah A. S., Fletcher, Steven, Fong, Kenny   +3 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Communication-Less Data-Driven Coordination Technique for Hybrid AC/DC Transmission Networks

Energies
There is a paradigm shift to hybrid (AC/DC) networks that integrate both AC and DC to meet growing energy demands, mitigate global warming, and interconnect distributed energy sources (DERs).
Arif Mehdi, Syed Jarjees Ul Hassan, Zeeshan Haider, Ho-Young Kim, Arif Hussain   +4 more
doaj   +1 more source