Results 41 to 50 of about 18,534 (262)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Fault Attacks on the Authenticated Encryption Stream Cipher MORUS

Cryptography, 2018
This paper investigates the application of fault attacks to the authenticated encryption stream cipher algorithm MORUS. We propose fault attacks on MORUS with two different goals: one to breach the confidentiality component, and the other to breach the ...
Iftekhar Salam, Leonie Simpson, Harry Bartlett, Ed Dawson, Kenneth Koon-Ho Wong   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Shipboard power system dynamic reconfiguration optimization strategy considering time-varying load characteristics

Zhongguo Jianchuan Yanjiu
ObjectivesIn order to ensure the safe and stable operation of a shipboard power system under fault conditions, a dynamic reconfiguration optimization method is proposed that considers time-varying load characteristics.MethodsFirst, considering the ...
Qihuan WU, Zhiyu ZHU, Weihan HAO, Denghao YANG, Cheng XU   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Urban distribution network reconfiguration strategy considering electric vehicles

Diance yu yibiao
Distribution network faults are directly related to users, and it is important to improve its fault recovery capability. In addition, with the gradual popularity of electric vehicle (EV), it has great potential to be used as a distributed energy storage ...
LIU Shu, SHI Shanshan, ZHOU Zheng, JIA Shicheng, LIAO Kai   +4 more
doaj   +1 more source

A Nonlinear Dynamic Current Deviation Control Method for Suppressing Continuous Commutation Failures in UHVDC Systems

Zhongguo dianli, 2021
Aiming at the continuous commutation failures in LCC-HVDC systems, a nonlinear dynamic current deviation control method is proposed. The operation curve of current deviation controller is dynamically adjusted according to the severity of AC faults ...
Bo YUAN, Ying WANG, Hua SHAO, Qianmao ZHANG, Liangdong QIN, Ningning LIU, Zhihui DAI   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Bayesian Network Based Fault Tolerance in Distributed Sensor Networks

Journal of Telecommunications and Information Technology, 2014
A Distributed Sensor Network (DSN) consists of a set of sensors that are interconnected by a communication network. DSN is capable of acquiring and processing signals, communicating, and performing simple computational tasks. Such sensors can detect and
B. Bhajantri Lokesh, N. Nalini
doaj   +1 more source