Results 61 to 70 of about 27,148 (264)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Adaptive Online Fault Diagnosis in Autonomous Robot Swarms

Frontiers in Robotics and AI, 2018
Previous work has shown that robot swarms are not always tolerant to the failure of individual robots, particularly those that have only partially failed and continue to contribute to collective behaviors.
James O'Keeffe, Danesh Tarapore, Alan G. Millard, Jon Timmis   +3 more
doaj   +1 more source

Fault-tolerant geometric spanners [PDF]

Proceedings of the nineteenth annual symposium on Computational geometry, 2003
We present two new results about vertex and edge fault-tolerant spanners in Euclidean spaces. We describe the first construction of vertex and edge fault-tolerant spanners having optimal bounds for maximum degree and total cost. We present a greedy algorithm that for any \(t > 1\) and any non-negative integer \(k\), constructs a \(k\)-fault-tolerant ...
Artur Czumaj, Hairong Zhao
openaire   +1 more source

Real-time fault diagnosis and fault-tolerant control [PDF]

, 2015
This "Special Section on Real-Time Fault Diagnosis and Fault-Tolerant Control" of the IEEE Transactions on Industrial Electronics is motivated to provide a forum for academic and industrial communities to report recent theoretic/application results in ...
Cecati, Carlo, Ding, Steven X., Gao, Zhiwei   +2 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Networking Microcontrollers and Balancing the Load on the Service Servers to Enhance the Fault Tolerance of the IoT Networks

Mathematics
Different types of faults occur in different layers of IoT networks, which affect their fault tolerance. The Controller and Services layers are the weakest links in an IoT network, and any failure in these layers drastically reduces its fault tolerance ...
Sastry Kodanda Rama Jammalamadaka, Bhupati Chokra, Sasi Bhanu Jammalamadaka, Balakrishna Kamesh Duvvuri   +3 more
doaj   +1 more source

Reducing the Energy Consumption in Fault-Tolerant Distributed Embedded Systems with Time-Constraints

, 2007
In this paper we address the problem of reducing the energy consumption in distributed embedded systems associated with time-constraints and equipped with fault-tolerant techniques. A greedy heuristic is presented to reduce the energy during task mapping
Yuan Cai, Cai, Yuan, Sudhakar M. Reddy, M. Reddy, Sudhakar, Al-Hashimi, Bashir M., Bashir M. Al-hashimi   +5 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Fault location of distribution networks based on multi-source information

Global Energy Interconnection, 2020
In order to promote the development of the Internet of Things (loT), there has been an increase in the coverage of the customer electric information acquisition system (CEIAS).
Wenbo Li, Jianjun Su, Xin Wang, Jiamei Li, Qian Ai   +4 more
doaj   +1 more source