Results 61 to 70 of about 237,861 (283)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
What does fault tolerant Deep Learning need from MPI?
, 2017 Deep Learning (DL) algorithms have become the de facto Machine Learning (ML) algorithm for large scale data analysis. DL algorithms are computationally expensive - even distributed DL implementations which use MPI require days of training (model learning)
Amatya, Vinay +3 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Adaptive Online Fault Diagnosis in Autonomous Robot Swarms
Frontiers in Robotics and AI, 2018 Previous work has shown that robot swarms are not always tolerant to the failure of individual robots, particularly those that have only partially failed and continue to contribute to collective behaviors.
James O'Keeffe +3 more
doaj +1 more source
An approach to rollback recovery of collaborating mobile agents [PDF]
, 2004 Fault-tolerance is one of the main problems that must be resolved to improve the adoption of the agents' computing paradigm. In this paper, we analyse the execution model of agent platforms and the significance of the faults affecting their constituent ...
Bargiela, A, Osman, T, Wagealla, W
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Measuring the BDARX architecture by agent oriented system a case study [PDF]
, 2018 Distributed systems are progressively designed as multi-agent systems that are helpful in designing high strength complex industrial software. Recently, distributed systems cooperative applications are openly access, dynamic and large scales.
Abdul Hamid, Noorhamreeza +6 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Fault-Tolerant Sequential Scan [PDF]
Theory of Computing Systems, 2007 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Flocchini, Paola +2 more
openaire +2 more sources