Results 91 to 100 of about 276,970 (242)

FAULT MAPPING BY DATA OF AEROSPACE SURVEYS TO ENSURE THE SAFETY OF MAIN PIPELINES (FOR EXAMPLE OF THE SECTION CHAYVO-DE-KASTRI PIPELINE)

Известия Томского политехнического университета: Инжиниринг георесурсов, 2023
Link for citation: Kuptsova O.V., Melkiy V.A., Verkhoturov A.A., Dolgopolov D.V. Fault mapping by data of aerospace surveys to ensure the safety of main pipelines (by the example of the section Chayvo–De-Kastri oil pipeline).
Olesya V. Kuptsova, Vyacheslav A. Melkiy, Alexey A. Verkhoturov, Daniil V. Dolgopolov   +3 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The geometry and thickness of deformation-band fault core and its influence on sealing characteristics of deformation-band fault zones [PDF]

, 2005
Deformation-band faults in high-porosity reservoir sandstones commonly contain a fault core of intensely crushed rock surrounding the main slip surfaces.
Thompson, L.B., Shipton, Z.K., Evans, J.P.   +2 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Prospects of productive strata of the pre-Jurassic complex of Western Siberia for the discovery and involvement in the development

Известия высших учебных заведений: Нефть и газ
The article discusses the prospects of productive strata of deposits of the pre-Jurassic complex of Western Siberia for searching, forecasting and involving in the development.
S. R. Bembel, R. M. Bembel, D. O. Karpov
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

MODEL OF PROCESS FOR ENSURING FAULT TOLERANCE IN INTERNET OF THINGS NETWORKS

Компютерні системи та інформаційні технології
The paper presents a model for providing fault tolerance in the Internet of Things network, describes key concepts, entities and connections, and also defines the main stages and processes that are included in providing fault tolerance.
Andrii NICHEPORUK, Oleksandr DARIYCHUK, Serhii DANCHUK   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Estimation Top and Bottom of Bogor Fault, Kepahiang Regency Based on 2D Magnetotelluric Data Analysis

JGEET: Journal of Geoscience, Engineering, Environment and Technology
Kepahiang Regency, Bengkulu Province, is an area crossed by the Musi segment of the Sumatra Fault and a number of secondary faults, including the Bogor Fault, which contribute to the high level of seismic activity in the region.
Zaky Muammar, Muchammad Farid, Arif Ismul Hadi, Tedy Algozali, Andre Rahmat Al Ansory, Hana Raihana   +5 more
doaj   +1 more source