Results 81 to 90 of about 1,457,944 (352)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Microhardness of Coal from Near-Fault Zones in Coal Seams Threatened with Gas-Geodynamic Phenomena, Upper Silesian Coal Basin, Poland

open access: yesEnergies, 2019
Near-fault coal displays some specific structural and textural features. As the distance to the fault diminishes, one can observe ever stronger, gradual degradation of coal, demonstrated by the emergence of structural distortions exogenic in their origin,
Katarzyna Godyń, Alena Kožušníková
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Fault Detection and Diagnosis in Air Conditioners and Refrigerators [PDF]

open access: yes, 1999
A fault detection and diagnosis (FDD) method was used to detect and diagnose faults on both a refrigerator and an air conditioner during normal cycling operation.
Bullard, C.W.   +2 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

How do normal faults grow?

open access: yesJournal of Structural Geology, 2015
Normal faults grow via synchronous increase in displacement and length (‘propagating fault model’, also known as the ‘isolated fault model’), or by rapid length establishment and subsequent displacement accrual (constant-length fault model).
A. Rotevatn   +4 more
semanticscholar   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Quantifying the slip rates, spatial distribution and evolution of active normal faults from geomorphic analysis: Field examples from an oblique-extensional graben, southern Turkey [PDF]

open access: yes, 2009
Quantifying the extent to which geomorphic features can be used to extract tectonic signals is a key challenge in the Earth Sciences. Here we analyse the drainage patterns, geomorphic impact, and long profiles of bedrock rivers that drain across and ...
Boulton, SJ, Whittaker, AC
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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