Results 121 to 130 of about 133,640 (303)
An overview of the ant fauna (Hymenoptera: Formicidae) of the state of Maranhão, Brazil
, 2019 Lívia Pires do Prado, Rodrigo M. Feitosa, Stefania Pinzón Triana, Jhonatan Andrés Muñoz Gutiérrez, Guillaume Xavier Rousseau, Raimunda Alves Silva, Glécio Machado Siqueira, Ciro Líbio Caldas dos Santos, Francisco Veras Silva, Thiago Silva, Alexandre Casadei‐Ferreira, Rogério Rosa da Silva, Joudellys Andrade‐Silva +12 moreopenalex +2 more sourcesCDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane +12 morewiley +1 more sourceReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceLiquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen +2 morewiley +1 more sourceAbundance of benthic sessile fauna associated with ARMS from the research" Evaluation of the use of Autonomous Reef Monitoring Structures (ARMS) for capturing the biological diversity of two coral reefs in the Yucatán Península, México " using the point intersection method (400 points per plate on each side) with the CPCe v4.1 soft-ware (Coral Point Count with Excel extension v4.1)
, 2021 A. Palomino-Alvarez L., G. Vital X., R. Castillo, Y. Suárez-Mozo. N., Diana Ugalde, G. Cervantes-Campero., M. Muciño-Reyes, P. Homá-Canché, Q. Hernández, Rosa Carmen Sotelo-Casas, M. García-González, A. Avedaño-Peláez Y., A. Hernández, E. Paz-Ríos C., M. Lizaola J., M. García-Venegas, Y. Dávila-Jiménez., Deneb Ortigosa, G. Hidalgo, José Luis Tello‐Musi, Mariana Rivera-Higueras, R. Mendoza-Moreno, K. Wicksten M, R. Rocha M., M. Viera L., Berenít Mendoza-Garfías, Nuno Simões, E. Guerra-Castro J. +27 moreopenalex +1 more sourceClass IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio +13 morewiley +1 more sourceIn vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow +10 morewiley +1 more source
