Results 201 to 210 of about 251,145 (305)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Serological evidence of Borrelia turicatae in Raccoons (Procyon lotor) from an endemic focus of tick-borne relapsing fever in Mexico. [PDF]

PLoS Negl Trop Dis
Hernández Martínez JA, Leal-Sepúlveda V, Zavala-Norzagaray AA, Rendón-Franco E, Ley-Quiñonez CP, Pellegrini-Hernández P, Lopez JE, Ibarra JA.   +7 more
europepmc   +1 more source

Auchenorrhyncha (Hemiptera) from Crete deposited at the Natural History Museum of Crete. [PDF]

Biodivers Data J
Angelova R, Gjonov I, Trichas A.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A new genus of giant salamander (Urodela, Cryptobranchidae) from the Pliocene of Japan. [PDF]

PeerJ
Noda M, Matsui M, Nishikawa K.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Isolated mycobiota from carcasses of wild animals run over on Highway 493 in Seropédica, Rio de Janeiro, Brazil. [PDF]

Braz J Vet Med
Pardão CAA, da Silva JF, Pereira JASM, Bonci MM, Matias CAR, de Oliveira ÁA.   +5 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Collaborative Conservation Genetics of Cryptic Reptile Taxa From Northern Australia. [PDF]

Ecol Evol
Campbell BL, Rangers Y, Rangers YM, Rangers N, Learning on Country – Laynhapuy Homelands School, Learning on Country – Shepherdson College, Dudaniec RY, Moritz C, Fenker J, Ens E.   +9 more
europepmc   +1 more source