Results 121 to 130 of about 24,384 (198)

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Impact of Monoclonal Antibody Aggregates on Effector Function Characterization

Antibodies
Background/Objectives: Monoclonal antibodies have successfully been used for a variety of indications. Many therapeutic antibodies are IgG1 and elicit effector functions as part of their mechanism of action.
Wendy J. Walton, Shousong Jason Zhang, Joseph J. Wilson, Briana N. Harvey, Matthew Clemens, Yingmei Gu   +5 more
doaj   +1 more source

Advancing IBD Management: A Literature Review on the Role of Non‐Invasive Blood‐Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein, Li Xi, Rathi D. Ryan, Zhan (Harold) Ye, Nessy Tania, Yamato Sano, Joshua Varghese, Diogo Branquinho, Anna Sapone   +8 more
wiley   +1 more source

Why Is MS a More Frequent Complication of EBV Infection in Females?

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Shannon E. Dunn, Nuria Alvarez‐Sanchez, Lawrence Steinman   +2 more
wiley   +1 more source

Positive and negative regulation of the Fcγ receptor-stimulating activity of RNA-containing immune complexes by RNase. [PDF]

JCI Insight, 2023
Naito R, Ohmura K, Higuchi S, Nakai W, Kohyama M, Mimori T, Morinobu A, Arase H.   +7 more
europepmc   +1 more source

Az adaptív immunválasz kialakulása és szabályozása fiziológiás és kóros körülmények között: dendritikus sejtek, hízósejtek és a komplementrendszer szerepének vizsgálata = Regulation of adaptive immune responses under normal and pathological conditions; role of dendritic cells, mastocytes and the complement system [PDF]

, 2009
A magasabbrendű szervezetek immunhomeosztázisát a veleszületett és az adaptív immunrendszer együtt tartja fenn; egymással szorosan összefonódva, folyamatosan együttműködve.
Bajtay, Zsuzsa, Erdei, Anna, László, Glória, Prechl, József   +3 more
core  

Extracellular domain 1 of human FcγRI (CD64) identified as the binding site for anti-FcγRI antibodies

mAbs
FcγRI (CD64) is the only Fcγ receptor capable of high-affinity binding to monomeric IgG and found on monocytes, macrophages, eosinophils, neutrophils, and dendritic cells.
Tosca Holtrop, Elsemieke M. Passchier, Sophie O’Toole, W. Joost Kraan, Kevin Budding, Jeanette H.W. Leusen   +5 more
doaj   +1 more source

Inhibition of BET Proteins Regulates Fcγ Receptor Function and Reduces Inflammation in Rheumatoid Arthritis. [PDF]

Int J Mol Sci, 2023
Shankar D, Merchand-Reyes G, Buteyn NJ, Santhanam R, Fang H, Kumar K, Mo X, Ganesan LP, Jarjour W, Butchar JP, Tridandapani S.   +10 more
europepmc   +1 more source

Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG. [PDF]

MAbs, 2023
Crowley AR, Mehlenbacher MR, Sajadi MM, DeVico AL, Lewis GK, Ackerman ME.   +5 more
europepmc   +1 more source