Results 121 to 130 of about 2,166 (230)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Sweet Relief? Short-Term Post-Traumatic High-Sucrose Intake Attenuates Acute but Not Long-Term Fear Responses in Mice. [PDF]

Biomedicines
Kumar P, Correia P, Plangár I, Zelena D.   +3 more
europepmc   +1 more source

Two Generalizations of Hopfian Abelian Groups

This paper targets to generalize the notion of Hopfian groups in the commutative case by defining the so-called {\bf relatively Hopfian groups} and {\bf weakly Hopfian groups}, and establishing some their crucial properties and characterizations ...
Danchev, Peter V., Keef, Patrick W., Chekhlov, Andrey R., Goldsmith, Brendan   +3 more
core  

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

A New Method for Dynamic Brain Connectivity Analysis Based on Tensor Decomposition in Tinnitus Using High-density Electroencephalogram in Source Domain. [PDF]

J Med Signals Sens
Bahman M, Sajadi SS, Toostani IG, MakkiAbadi B.   +3 more
europepmc   +1 more source

A Rare Allele of ST5 From Wild Rice Enhances Salt Tolerance in Rice

Advanced Science, EarlyView.
A novel salt‐tolerance gene ST5W, characterized by a unique 36‐bp promoter insertion, is found exclusively in a small subset of Oryza rufipogon and is absent in cultivated rice. Field trials confirm ST5W significantly enhances rice yield across diverse genetic backgrounds under saline conditions.
Meng Xing, Jingfen Huang, Qiaoling Yuan, Ziyi Yang, Yanyan Wang, Mingchao Zhao, Yamin Nie, Rui Xu, Hongge Qian, Wenxi Chen, Qiaoling Zhang, Qi Du, Leiyue Geng, Yapeng Li, Ziyi Chen, Shizhuang Wang, Like Lou, Haiyuan Peng, Chongke Zheng, Xianzhi Xie, Xiaoming Zheng, Lifang Zhang, Lianguang Shang, Jiaqiang Sun, Qian Qian, Qingwen Yang, Weihua Qiao   +26 more
wiley   +1 more source

Dynamical study of different types of soliton solutions with bifurcation, chaos and sensitivity analysis to the non-linear coupled Schrödinger model. [PDF]

Sci Rep
Nasir R, Abbas M, Alharthi MR, Nazir T, Yousaf MZ, Birhanu A.   +5 more
europepmc   +1 more source

On Sylow theorems and their generalizations for finite solvalbe groups

, 2015
Tutkielman tarkoituksena on yleistää Sylowin lauseet äärellisille ratkeaville ryhmille. Tutkielma on kirjoitettu pääasiassa Joseph Rotmanin teoksen ”Graduate Texts in Mathematics; An Introduction to the Theory of Groups” (Springer-Verlag, New York, 1995)
Väisänen, Sara
core  

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Different dimensions of oral health literacy and tooth avulsion management: pre-post study with schoolteachers. [PDF]

Braz Oral Res
Fagundes FAU, Schade AC, Dias VFO, Fraiz FC, Ferreira FM, Assunção LRDS.   +5 more
europepmc   +1 more source