Results 21 to 30 of about 305,461 (343)

Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors

Frontiers in Immunology, 2021
Rhesus macaques are a common non-human primate model used in the evaluation of human monoclonal antibodies, molecules whose effector functions depend on a conserved N-linked glycan in the Fc region.
Andrew R. Crowley, Nana Yaw Osei-Owusu, Gillian Dekkers, Wenda Gao, Manfred Wuhrer, Diogo M. Magnani, Keith A. Reimann, Seth H. Pincus, Seth H. Pincus, Gestur Vidarsson, Margaret E. Ackerman, Margaret E. Ackerman   +11 more
doaj   +1 more source

Fc-engineered antibodies with immune effector functions completely abolished.

PLoS ONE, 2021
Elimination of the binding of immunoglobulin Fc to Fc gamma receptors (FcγR) is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins.
Ian Wilkinson, Stephen Anderson, Jeremy Fry, Louis Alex Julien, David Neville, Omar Qureshi, Gary Watts, Geoff Hale   +7 more
doaj   +1 more source

The Diverse Functions of the Ubiquitous Fcγ Receptors and Their Unique Constituent, FcRγ Subunit

Pathogens, 2020
Fc gamma receptors (FcγRs) are widely expressed on a variety of immune cells and play a myriad of regulatory roles in the immune system because of their structural diversity.
Thamer A. Hamdan, Philipp A. Lang, Karl S. Lang   +2 more
doaj   +1 more source

Evolutionary analyses of polymeric immunoglobulin receptor (pIgR) in the mammals reveals an outstanding mutation rate in the lagomorphs

Frontiers in Immunology, 2022
BackgroundThe transcytosis of polymeric immunoglobulins, IgA and IgM, across the epithelial barrier to the luminal side of mucosal tissues is mediated by the polymeric immunoglobulin receptor (pIgR).
Fabiana Neves, Fabiana Neves, Patrícia de Sousa-Pereira, Patrícia de Sousa-Pereira, Patrícia de Sousa-Pereira, José Melo-Ferreira, José Melo-Ferreira, José Melo-Ferreira, Pedro J. Esteves, Pedro J. Esteves, Pedro J. Esteves, Pedro J. Esteves, Ana Pinheiro, Ana Pinheiro   +13 more
doaj   +1 more source

Human mast cell activation through Fc receptors and Toll-like receptors

Allergology International, 2004
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE.
Yoshimichi Okayama, Shigeru Okumura, Hisashi Tomita, Hiroko Katayama, Keisuke Yuki, Shinji Kagaya, Jun-ichi Kashiwakura, Hirohisa Saito   +7 more
doaj   +1 more source

Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa [PDF]

, 2016
The Fc region of Immunoglobulin G (IgG) initiates inflammatory responses such as antibody-dependent cell-mediated cytotoxicity (ADCC) through binding to activating Fc receptors (FcγRI, FcγRIIa, FcγRIIIa).
Ahmed, Alysia A., Bjorkman, Pamela J., Keremane, Sravya R., Vielmetter, Jost   +3 more
core   +2 more sources

Pentraxins and Fc Receptor-Mediated Immune Responses

Frontiers in Immunology, 2018
C-reactive protein (CRP) is a member of the pentraxin family of proteins. These proteins are highly conserved over the course of evolution being present as far back as 250 million years ago.
Jinghua Lu, Carolyn Mold, Carolyn Mold, Terry W. Du Clos, Peter D. Sun   +4 more
doaj   +1 more source

Multimerization strategies for efficient production and purification of highly active synthetic cytokine receptor ligands.

PLoS ONE, 2020
Cytokine signaling is transmitted by cell surface receptors which act as natural biological switches to control cellular functions such as immune reactions.
Sofie Mossner, Hoang T Phan, Saskia Triller, Jens M Moll, Udo Conrad, Jürgen Scheller   +5 more
doaj   +1 more source

pH Dependence and Stoichiometry of Binding to the Fc Region of IgG by the Herpes Simplex Virus Fc Receptor gE-gI [PDF]

, 2004
Herpes simplex virus type 1 encodes two glycoproteins, gE and gI, that form a heterodimer on the surface of virions and infected cells. The gE-gI heterodimer has been implicated in cell-to-cell spread of virus and is a receptor for the Fc fragment of IgG.
Bjorkman, Pamela J., Martin, W. Lance, Sprague, Elizabeth R.   +2 more
core   +1 more source

IgA Fc Receptors

Annual Review of Immunology, 2003
The IgA receptor family comprises a number of surface receptors including the polymeric Ig receptor involved in epithelial transport of IgA/IgM, the myeloid specific IgA Fc receptor (FcαRI or CD89), the Fcα/μR, and at least two alternative IgA receptors.
Monteiro, R.C., van de Winkel, J.G.J.
openaire   +3 more sources