Fc receptors for immunoglobulins and their appearance during vertebrate evolution. [PDF]
PLoS ONE, 2014 Receptors interacting with the constant domain of immunoglobulins (Igs) have a number of important functions in vertebrates. They facilitate phagocytosis by opsonization, are key components in antibody-dependent cellular cytotoxicity as well as ...
Srinivas Akula +2 more
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Fc receptors act as innate immune receptors during infection? [PDF]
Frontiers in Immunology, 2023 Innate immunity constitutes the first nonspecific immunological line of defense against infection. In this response, a variety of mechanisms are activated: the complement system, phagocytosis, and the inflammatory response.
Chaimaa Laassili +9 more
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Inside-Out Control of Fc-Receptors [PDF]
Frontiers in Immunology, 2019 Receptors recognizing the Fc-part of immunoglobulins (FcR) are important in the engagement of phagocytes with opsonized micro-organisms, but they also play a major role in the pathogenesis of chronic inflammatory diseases. Different FcRs are specifically
Leo Koenderman
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Changes in the Interaction Properties of Antibodies with Fc Receptors upon Binding to Target Antigens [PDF]
BiosensorsThe interaction of therapeutic antibodies with Fc receptors is an important property that is actively modified to improve pharmacokinetic profiles and optimize antibody-dependent mechanisms of action.
Artem S. Grevtsev +9 more
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Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV [PDF]
Cell ReportsSummary: Antibodies binding cell-surface antigens to activate cellular immunity are an important mechanism of anti-viral protection, yet antibodies targeting cells infected by human cytomegalovirus (HCMV) exhibit limited efficacy.
Ahlam N. Qerqez +19 more
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NEW ROLES FOR FC RECEPTORS IN NEURODEGENERATION-THE IMPACT ON IMMUNOTHERAPY FOR ALZHEIMER’S DISEASE [PDF]
Frontiers in Neuroscience, 2014 There are an estimated 18 million Alzheimer’s disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
James P. Fuller +2 more
doaj +4 more sources
Characterization of the Interaction between the Herpes Simplex Virus Type I Fc Receptor and Immunoglobulin G [PDF]
, 1999 Herpes simplex virus type I (HSV-1) virions and HSV-1-infected cells bind to human immunoglobulin G (hIgG) via its Fc region. A complex of two surface glycoproteins encoded by HSV-1, gE and gI, is responsible for Fc binding.
Tara L. Chapman +5 more
openalex +4 more sources
IgG fc receptors provide an alternative infection route for murine gamma-herpesvirus-68.
PLoS ONE, 2007 BackgroundHerpesviruses can be neutralized in vitro but remain infectious in immune hosts. One difference between these settings is the availability of immunoglobulin Fc receptors. The question therefore arises whether a herpesvirus exposed to apparently
Gustavo T Rosa +4 more
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Corrigendum: Inside-Out Control of Fc-Receptors [PDF]
Frontiers in Immunology, 2019 Leo Koenderman
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Editorial: Roles of Fc Receptors in Disease and Therapy [PDF]
Frontiers in Immunology, 2020 Latha P. Ganesan +2 more
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