Results 11 to 20 of about 159,090 (257)

The Diverse Functions of the Ubiquitous Fcγ Receptors and Their Unique Constituent, FcRγ Subunit

Pathogens, 2020
Fc gamma receptors (FcγRs) are widely expressed on a variety of immune cells and play a myriad of regulatory roles in the immune system because of their structural diversity.
Thamer A. Hamdan, Philipp A. Lang, Karl S. Lang   +2 more
doaj   +1 more source

Evolutionary analyses of polymeric immunoglobulin receptor (pIgR) in the mammals reveals an outstanding mutation rate in the lagomorphs

Frontiers in Immunology, 2022
BackgroundThe transcytosis of polymeric immunoglobulins, IgA and IgM, across the epithelial barrier to the luminal side of mucosal tissues is mediated by the polymeric immunoglobulin receptor (pIgR).
Fabiana Neves, Fabiana Neves, Patrícia de Sousa-Pereira, Patrícia de Sousa-Pereira, Patrícia de Sousa-Pereira, José Melo-Ferreira, José Melo-Ferreira, José Melo-Ferreira, Pedro J. Esteves, Pedro J. Esteves, Pedro J. Esteves, Pedro J. Esteves, Ana Pinheiro, Ana Pinheiro   +13 more
doaj   +1 more source

Fc RECEPTORS AND THEIR INTERACTIONS WITH IMMUNOGLOBULINS [PDF]

Annual Review of Cell and Developmental Biology, 1996
▪ Abstract  Receptors for the Fc domain of immunoglobulins play an important role in immune defense. There are two well-defined functional classes of mammalian receptors. One class of receptors transports immunoglobulins across epithelial tissues to their main sites of action.
Raghavan, Malini, Bjorkman, Pamela J.
openaire   +3 more sources

Human mast cell activation through Fc receptors and Toll-like receptors

Allergology International, 2004
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE.
Yoshimichi Okayama, Shigeru Okumura, Hisashi Tomita, Hiroko Katayama, Keisuke Yuki, Shinji Kagaya, Jun-ichi Kashiwakura, Hirohisa Saito   +7 more
doaj   +1 more source

Receptor for Fc on the Surfaces of Schistosomes [PDF]

Infection and Immunity, 2001
ABSTRACTSchistosoma mansonimasks its surface with adsorbed host proteins including erythrocyte antigens, immunoglobulins, major histocompatibility complex class I, and β2-microglobulin (β2m), presumably as a means of avoiding host immune responses. How this is accomplished has not been explained.
Loukas, Alex, Jones, Malcolm K., King, Lynette T., Brindley, Paul J., McManus, Donald P.   +4 more
openaire   +5 more sources

Pentraxins and Fc Receptor-Mediated Immune Responses

Frontiers in Immunology, 2018
C-reactive protein (CRP) is a member of the pentraxin family of proteins. These proteins are highly conserved over the course of evolution being present as far back as 250 million years ago.
Jinghua Lu, Carolyn Mold, Carolyn Mold, Terry W. Du Clos, Peter D. Sun   +4 more
doaj   +1 more source

Multimerization strategies for efficient production and purification of highly active synthetic cytokine receptor ligands.

PLoS ONE, 2020
Cytokine signaling is transmitted by cell surface receptors which act as natural biological switches to control cellular functions such as immune reactions.
Sofie Mossner, Hoang T Phan, Saskia Triller, Jens M Moll, Udo Conrad, Jürgen Scheller   +5 more
doaj   +1 more source

Fc Receptors

, 2008
The aggregation of cell surface Fc receptors by immune complexes induces a number of important antibody-dependent effector functions. It is becoming increasingly evident that the organization of key immune proteins has a significant impact on the function of these proteins.
Maree S, Powell, P Mark, Hogarth
  +6 more sources

A homogeneous bioluminescent immunoassay for parallel characterization of binding between a panel of antibodies and a family of Fcγ receptors

Scientific Reports, 2022
Fc engineering efforts are increasingly being employed to modulate interaction of antibodies with variety of Fc receptors in an effort to improve the efficacy and safety of the therapeutic antibodies.
Nidhi Nath, Becky Godat, Rod Flemming, Marjeta Urh   +3 more
doaj   +1 more source

Immunoglobulin G1 binding with various molecular receptors: A new paradigm of IgG1 as a potential adjuvant

Journal of Acute Disease, 2019
Objective: To explore the possible IgG1 binding receptors by protein-protein docking experiments. Methods: The protein-protein cognate interactions such as IgG with Fc Receptors (FcRs) potentiate signaling cascades to ameliorate antigen uptake ...
Shweta Saxena, Vignesh Sounderrajan, Saravanan Konda Mani, Shakila Harshavardhan   +3 more
doaj   +1 more source