Results 1 to 10 of about 296,832 (268)

IgG binding characteristics of ferret Fcγ receptors [PDF]

mAbs
Studies in animal models are essential to expanding the scope of interventions evaluated for safety, immunogenicity, and efficacy in clinical trials.
Xiaoxuan Ge, Matthew Stoner, Joshua A. Weiner, Melanee E. Balderas Hernández, Noor Taher, Urjeet S. Khanwalkar, Margaret C. Carpenter, Jiwon Lee, Margaret E. Ackerman   +8 more
doaj   +2 more sources

Fcγ receptors on aging neutrophils [PDF]

Journal of Applied Oral Science, 2021
Objective Neutrophils are key effector cells of the innate immune system. They recognize antigens through membrane receptors, which are expressed during their maturation and activation. Neutrophils express FcγRII (CD32), FcγRIII (CD16), and FcγRI (CD64)
Thaís Helena GASPAROTO, Thalita Marcato DALBONI, Nádia Ghinelli AMÔR, Aneli Eiko ABE, Graziela PERRI, Vanessa Soares LARA, Narciso Almeida VIEIRA, Carlos Teodoro GASPAROTO, Ana Paula CAMPANELLI   +8 more
doaj   +1 more source

Effect of IgG dimer concentration on the binding ability of IgG Fc fragment in IVIG to THP-1 cell surface receptors

Zhongguo shuxue zazhi, 2023
Objective To investigate the effect of immunoglobulin G (IgG) dimer concentration of intravenous immunoglobulin (IVIG) on the binding ability of IgG Fc fragment to THP-1 cell surface receptors.
Tingting LEI, Wei ZHANG, Changqing LI, Shengliang YE, Xi DU, Li MA   +5 more
doaj   +1 more source

Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG

mAbs, 2023
Antibody-mediated effector functions are widely considered to unfold according to an associative model of IgG-Fcγ receptor (FcγR) interactions. The associative model presupposes that Fc receptors cannot discriminate antigen-bound IgG from free IgG in ...
Andrew R. Crowley, Matthew R. Mehlenbacher, Mohammad M. Sajadi, Anthony L. DeVico, George K. Lewis, Margaret E. Ackerman   +5 more
doaj   +1 more source

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors. [PDF]

PLoS ONE, 2015
Antigen-specific IgG antibodies, passively administered to mice or humans together with large particulate antigens like erythrocytes, can completely suppress the antibody response against the antigen.
Joakim J E Bergström, Birgitta Heyman
doaj   +1 more source

Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy postmenopause

Frontiers in Endocrinology, 2023
IntroductionThe glycosylation of immunoglobulin (Ig) G regulates IgG interaction capability with Fc gamma receptors found in all immune cells. In pathogenic conditions, estrogen can impact IgG levels and glycosylation.
Priti Gupta, Priti Gupta, Priti Gupta, Tibor Sághy, Tibor Sághy, Tibor Sághy, Jauquline Nordqvist, Jonas Nilsson, Hans Carlsten, Karin Horkeby, Petra Henning, Cecilia Engdahl, Cecilia Engdahl, Cecilia Engdahl   +13 more
doaj   +1 more source

C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc Receptors in vitro

Frontiers in Immunology, 2021
Antibody-mediated blood disorders ensue after auto- or alloimmunization against blood cell antigens, resulting in cytopenia. Although the mechanisms of cell destruction are the same as in immunotherapies targeting tumor cells, many factors are still ...
A. Robin Temming, Matthias Tammes Buirs, Arthur E. H. Bentlage, Louise W. Treffers, Hannah Feringa, Steven W. de Taeye, Steven W. de Taeye, Taco W. Kuijpers, Taco W. Kuijpers, Sietse Q. Nagelkerke, Sietse Q. Nagelkerke, Giso Brasser, Juk Yee Mok, Wim J. E. van Esch, Timo K. van den Berg, Theo Rispens, C. Ellen van der Schoot, Gestur Vidarsson   +17 more
doaj   +1 more source

Fc receptors for immunoglobulins and their appearance during vertebrate evolution. [PDF]

PLoS ONE, 2014
Receptors interacting with the constant domain of immunoglobulins (Igs) have a number of important functions in vertebrates. They facilitate phagocytosis by opsonization, are key components in antibody-dependent cellular cytotoxicity as well as ...
Srinivas Akula, Sayran Mohammadamin, Lars Hellman   +2 more
doaj   +1 more source

The Neonatal Fc Receptor (FcRn): A Misnomer?

Frontiers in Immunology, 2019
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik, Kine M. K. Sand, Kine M. K. Sand, Jonathan J. Hubbard, Jonathan J. Hubbard, Jan Terje Andersen, Jan Terje Andersen, Inger Sandlie, Richard S. Blumberg, Richard S. Blumberg   +9 more
doaj   +1 more source

Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages

mBio, 2021
Viruses infect cells mainly via specific receptors at the cell surface. Antibody-dependent enhancement (ADE) of infection is an alternative mechanism of infection for viruses to infect immune cells that is mediated by antibodies and IgG receptors (FcγRs).
Tadashi Maemura, Makoto Kuroda, Tammy Armbrust, Seiya Yamayoshi, Peter J. Halfmann, Yoshihiro Kawaoka   +5 more
doaj   +1 more source