Results 1 to 10 of about 159,070 (244)
Fc effector functions in RNA viral infections: mechanisms of antiviral immunity and implications for vaccine design [PDF]
Frontiers in ImmunologyNeutralizing antibodies (NAbs) have long been the principal correlate of antiviral protection. Evidence now indicates that antibody Fc-mediated effector functions play indispensable and context-dependent roles in antiviral immunity.
Jiale Zhang +9 more
doaj +2 more sources
Fc receptors act as innate immune receptors during infection?
Frontiers in Immunology, 2023 Innate immunity constitutes the first nonspecific immunological line of defense against infection. In this response, a variety of mechanisms are activated: the complement system, phagocytosis, and the inflammatory response.
Chaimaa Laassili +9 more
doaj +1 more source
Frontiers in Immunology, 2021 Rhesus macaques are a common non-human primate model used in the evaluation of human monoclonal antibodies, molecules whose effector functions depend on a conserved N-linked glycan in the Fc region.
Andrew R. Crowley +11 more
doaj +1 more source
Fc-engineered antibodies with immune effector functions completely abolished.
PLoS ONE, 2021 Elimination of the binding of immunoglobulin Fc to Fc gamma receptors (FcγR) is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins.
Ian Wilkinson +7 more
doaj +1 more source
The Diverse Functions of the Ubiquitous Fcγ Receptors and Their Unique Constituent, FcRγ Subunit
Pathogens, 2020 Fc gamma receptors (FcγRs) are widely expressed on a variety of immune cells and play a myriad of regulatory roles in the immune system because of their structural diversity.
Thamer A. Hamdan +2 more
doaj +1 more source
Fc RECEPTORS AND THEIR INTERACTIONS WITH IMMUNOGLOBULINS [PDF]
Annual Review of Cell and Developmental Biology, 1996 ▪ Abstract Receptors for the Fc domain of immunoglobulins play an important role in immune defense. There are two well-defined functional classes of mammalian receptors. One class of receptors transports immunoglobulins across epithelial tissues to their main sites of action.
Raghavan, Malini, Bjorkman, Pamela J.
openaire +3 more sources
Human mast cell activation through Fc receptors and Toll-like receptors
Allergology International, 2004 Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE.
Yoshimichi Okayama +7 more
doaj +1 more source
Receptor for Fc on the Surfaces of Schistosomes [PDF]
Infection and Immunity, 2001 ABSTRACTSchistosoma mansonimasks its surface with adsorbed host proteins including erythrocyte antigens, immunoglobulins, major histocompatibility complex class I, and β2-microglobulin (β2m), presumably as a means of avoiding host immune responses. How this is accomplished has not been explained.
Loukas, Alex +4 more
openaire +5 more sources
Pentraxins and Fc Receptor-Mediated Immune Responses
Frontiers in Immunology, 2018 C-reactive protein (CRP) is a member of the pentraxin family of proteins. These proteins are highly conserved over the course of evolution being present as far back as 250 million years ago.
Jinghua Lu +4 more
doaj +1 more source
PLoS ONE, 2020 Cytokine signaling is transmitted by cell surface receptors which act as natural biological switches to control cellular functions such as immune reactions.
Sofie Mossner +5 more
doaj +1 more source