Results 11 to 20 of about 299,300 (300)

NEW ROLES FOR FC RECEPTORS IN NEURODEGENERATION-THE IMPACT ON IMMUNOTHERAPY FOR ALZHEIMER’S DISEASE [PDF]

Frontiers in Neuroscience, 2014
There are an estimated 18 million Alzheimer’s disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
James P. Fuller, Jeffrey B. Stavenhagen, Jessica L. Teeling   +2 more
doaj   +4 more sources

Fc receptors for immunoglobulins and their appearance during vertebrate evolution. [PDF]

PLoS ONE, 2014
Receptors interacting with the constant domain of immunoglobulins (Igs) have a number of important functions in vertebrates. They facilitate phagocytosis by opsonization, are key components in antibody-dependent cellular cytotoxicity as well as ...
Srinivas Akula, Sayran Mohammadamin, Lars Hellman   +2 more
doaj   +8 more sources

Changes in the Interaction Properties of Antibodies with Fc Receptors upon Binding to Target Antigens [PDF]

Biosensors
The interaction of therapeutic antibodies with Fc receptors is an important property that is actively modified to improve pharmacokinetic profiles and optimize antibody-dependent mechanisms of action.
Artem S. Grevtsev, Anton A. Kommer, Irina S. Zelmanchuk, Andrei S. Avdiushkin, Elizaveta O. Ermolaeva, Aleksandr A. Tiulin, Darya O. Chernyshova, Alexandra D. Azarian, Alexandr A. Gordeev, Aleksey K. Misorin   +9 more
doaj   +2 more sources

Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV [PDF]

Cell Reports
Summary: Antibodies binding cell-surface antigens to activate cellular immunity are an important mechanism of anti-viral protection, yet antibodies targeting cells infected by human cytomegalovirus (HCMV) exhibit limited efficacy.
Ahlam N. Qerqez, Katja Hoffmann, Alison G. Lee, Sumit Pareek, Kelli Hager, Akaash K. Mishra, George Delidakis, Kirsten Bentley, Lauren Kerr-Jones, Mica Cabrera, Truong Nguyen, Rebecca L. Göttler, Amjad Chowdhury, Philipp L. Kolb, Hartmut Hengel, George Georgiou, Jason S. McLellan, Richard J. Stanton, Annalee W. Nguyen, Jennifer A. Maynard   +19 more
doaj   +2 more sources

Fc receptors act as innate immune receptors during infection?

Frontiers in Immunology, 2023
Innate immunity constitutes the first nonspecific immunological line of defense against infection. In this response, a variety of mechanisms are activated: the complement system, phagocytosis, and the inflammatory response.
Chaimaa Laassili, Fatiha Ben El Hend, Riad Benzidane, Loubna Oumeslakht, Abdel-Ilah Aziz, Rachid El Fatimy, Armand Bensussan, Armand Bensussan, Armand Bensussan, Sanae Ben Mkaddem   +9 more
doaj   +1 more source

Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors

Frontiers in Immunology, 2021
Rhesus macaques are a common non-human primate model used in the evaluation of human monoclonal antibodies, molecules whose effector functions depend on a conserved N-linked glycan in the Fc region.
Andrew R. Crowley, Nana Yaw Osei-Owusu, Gillian Dekkers, Wenda Gao, Manfred Wuhrer, Diogo M. Magnani, Keith A. Reimann, Seth H. Pincus, Seth H. Pincus, Gestur Vidarsson, Margaret E. Ackerman, Margaret E. Ackerman   +11 more
doaj   +1 more source

Fc-engineered antibodies with immune effector functions completely abolished.

PLoS ONE, 2021
Elimination of the binding of immunoglobulin Fc to Fc gamma receptors (FcγR) is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins.
Ian Wilkinson, Stephen Anderson, Jeremy Fry, Louis Alex Julien, David Neville, Omar Qureshi, Gary Watts, Geoff Hale   +7 more
doaj   +1 more source

The Diverse Functions of the Ubiquitous Fcγ Receptors and Their Unique Constituent, FcRγ Subunit

Pathogens, 2020
Fc gamma receptors (FcγRs) are widely expressed on a variety of immune cells and play a myriad of regulatory roles in the immune system because of their structural diversity.
Thamer A. Hamdan, Philipp A. Lang, Karl S. Lang   +2 more
doaj   +1 more source

Human mast cell activation through Fc receptors and Toll-like receptors

Allergology International, 2004
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE.
Yoshimichi Okayama, Shigeru Okumura, Hisashi Tomita, Hiroko Katayama, Keisuke Yuki, Shinji Kagaya, Jun-ichi Kashiwakura, Hirohisa Saito   +7 more
doaj   +1 more source

A homogeneous bioluminescent immunoassay for parallel characterization of binding between a panel of antibodies and a family of Fcγ receptors

Scientific Reports, 2022
Fc engineering efforts are increasingly being employed to modulate interaction of antibodies with variety of Fc receptors in an effort to improve the efficacy and safety of the therapeutic antibodies.
Nidhi Nath, Becky Godat, Rod Flemming, Marjeta Urh   +3 more
doaj   +1 more source