Results 21 to 30 of about 296,832 (268)

Immunoglobulin G1 binding with various molecular receptors: A new paradigm of IgG1 as a potential adjuvant

Journal of Acute Disease, 2019
Objective: To explore the possible IgG1 binding receptors by protein-protein docking experiments. Methods: The protein-protein cognate interactions such as IgG with Fc Receptors (FcRs) potentiate signaling cascades to ameliorate antigen uptake ...
Shweta Saxena, Vignesh Sounderrajan, Saravanan Konda Mani, Shakila Harshavardhan   +3 more
doaj   +1 more source

Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia

Journal of Neuroinflammation, 2022
Background There is growing evidence that neuroinflammation may contribute to schizophrenia neuropathology. Elevated pro-inflammatory cytokines are evident in the midbrain from schizophrenia subjects, findings that are driven by a subgroup of patients ...
A. Petty, L. J. Glass, D. A. Rothmond, T. Purves-Tyson, A. Sweeney, Y. Kondo, S. Kubo, M. Matsumoto, C. Shannon Weickert   +8 more
doaj   +1 more source

The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs [PDF]

The Journal of Immunology, 2003
Abstract Abs of the IgG isotype are efficiently transported from mother to neonate and have an extended serum t1/2 compared with Abs of other isotypes. Circumstantial evidence suggests that the MHC class I-related protein, the neonatal FcR (FcRn), is the FcR responsible for both in vivo functions.
Roopenian, D C, Christianson, G J, Sproule, T J, Brown, A C, Akilesh, S, Jung, N, Petkova, S, Avanessian, L, Choi, E Y, Shaffer, D J, Eden, P A, Anderson, C L   +11 more
openaire   +2 more sources

Pentraxins and Fc Receptor-Mediated Immune Responses

Frontiers in Immunology, 2018
C-reactive protein (CRP) is a member of the pentraxin family of proteins. These proteins are highly conserved over the course of evolution being present as far back as 250 million years ago.
Jinghua Lu, Carolyn Mold, Carolyn Mold, Terry W. Du Clos, Peter D. Sun   +4 more
doaj   +1 more source

Autoantibodies against muscarinic receptors in breast cancer: their role in tumor angiogenesis. [PDF]

PLoS ONE, 2013
The presence of autoantibodies in cancer has become relevant in recent years. We demonstrated that autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells.
María Gabriela Lombardi, María Pía Negroni, Laura Tatiana Pelegrina, María Ester Castro, Gabriel L Fiszman, María Eugenia Azar, Carlos Cresta Morgado, María Elena Sales   +7 more
doaj   +1 more source

Cellular surface plasmon resonance-based detection of anti-HPA-1a antibody glycosylation in fetal and neonatal alloimmune thrombocytopenia

Frontiers in Immunology, 2023
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate.
Zoltán Szittner, Zoltán Szittner, Arthur E. H. Bentlage, Arthur E. H. Bentlage, A. Robin Temming, A. Robin Temming, David E. Schmidt, David E. Schmidt, Remco Visser, Remco Visser, Suzanne Lissenberg-Thunnissen, Suzanne Lissenberg-Thunnissen, Juk Yee Mok, Wim J. E. van Esch, Myrthe E. Sonneveld, Myrthe E. Sonneveld, Erik L. de Graaf, Erik L. de Graaf, Manfred Wuhrer, Leendert Porcelijn, Masja de Haas, Masja de Haas, Masja de Haas, C. Ellen van der Schoot, C. Ellen van der Schoot, Gestur Vidarsson, Gestur Vidarsson   +26 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III. [PDF]

PLoS Pathogens, 2014
Human cytomegalovirus (HCMV) establishes lifelong infection with recurrent episodes of virus production and shedding despite the presence of adaptive immunological memory responses including HCMV immune immunoglobulin G (IgG).
Eugenia Corrales-Aguilar, Mirko Trilling, Katja Hunold, Manuela Fiedler, Vu Thuy Khanh Le, Henrike Reinhard, Katrin Ehrhardt, Eva Mercé-Maldonado, Enver Aliyev, Albert Zimmermann, David C Johnson, Hartmut Hengel   +11 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Fc Gamma Receptors as Regulators of Bone Destruction in Inflammatory Arthritis

Frontiers in Immunology, 2021
Bone erosion is one of the primary features of inflammatory arthritis and is caused by excessive differentiation and activation of osteoclasts. Fc gamma receptors (FcγRs) have been implicated in osteoclastogenesis.
Yuyue Zuo, Guo-Min Deng
doaj   +1 more source