Journal of Acute Disease, 2019 Objective: To explore the possible IgG1 binding receptors by protein-protein docking experiments. Methods: The protein-protein cognate interactions such as IgG with Fc Receptors (FcRs) potentiate signaling cascades to ameliorate antigen uptake ...
Shweta Saxena +3 more
doaj +1 more source
Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia
Journal of Neuroinflammation, 2022 Background There is growing evidence that neuroinflammation may contribute to schizophrenia neuropathology. Elevated pro-inflammatory cytokines are evident in the midbrain from schizophrenia subjects, findings that are driven by a subgroup of patients ...
A. Petty +8 more
doaj +1 more source
Studies of Fc receptors mediating IgG transport
, 1985 Suckling rats passively acquire immunity by receptor-mediated uptake of maternal immunoglobulin G (IgG) from colostrum and milk. Receptors for the Fc region of IgG mediate its internalisation at the brush borders of endothelial cells of the proximal ...
Simister, Neil E.
core +1 more source
Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B [PDF]
, 2005 The Fcγ receptors play important roles in the initiation and regulation of many immunological and inflammatory processes, and genetic variants (FCGR) have been associated with numerous autoimmune and infectious diseases. The data in rheumatoid arthritis (
Barrett , Jennifer H. +44 more
core +1 more source
Neonatal Fc receptor and IgG-based therapeutics [PDF]
mAbs, 2011 The majority of potent new biologics today are IgG-based molecules that have demonstrated tissue-targeting specificity with favorable clinical response. Several factors determine the efficacy of these products, including target specificity, serum half-life and effector functions via complement-dependent cytotoxicity, antibody-dependent cell-mediated ...
Timothy T, Kuo, Victoria G, Aveson
openaire +2 more sources
Pentraxins and Fc Receptor-Mediated Immune Responses
Frontiers in Immunology, 2018 C-reactive protein (CRP) is a member of the pentraxin family of proteins. These proteins are highly conserved over the course of evolution being present as far back as 250 million years ago.
Jinghua Lu +4 more
doaj +1 more source
Autoantibodies against muscarinic receptors in breast cancer: their role in tumor angiogenesis. [PDF]
PLoS ONE, 2013 The presence of autoantibodies in cancer has become relevant in recent years. We demonstrated that autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells.
María Gabriela Lombardi +7 more
doaj +1 more source
IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study. [PDF]
, 2015 IgG anti-apolipoprotein A-1 (IgG anti-apoA-1) antibodies are present in patients with systemic lupus erythematosus (SLE) and may link inflammatory disease activity and the increased risk of developing atherosclerosis and cardiovascular disease (CVD) in ...
Davari, M +19 more
core +1 more source
Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III. [PDF]
PLoS Pathogens, 2014 Human cytomegalovirus (HCMV) establishes lifelong infection with recurrent episodes of virus production and shedding despite the presence of adaptive immunological memory responses including HCMV immune immunoglobulin G (IgG).
Eugenia Corrales-Aguilar +11 more
doaj +1 more source
Frontiers in Immunology, 2023 Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate.
Zoltán Szittner +26 more
doaj +1 more source