Regulation of immune responses by the neonatal Fc receptor and its therapeutic implications [PDF]
Frontiers in Immunology, 2015 As a single receptor, the neonatal Fc receptor (FcRn) is critically involved in regulating albumin and IgG serum concentrations by protecting these two ligands from degradation.
Timo eRath +4 more
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Megalin Orchestrates FcRn Endocytosis and Trafficking [PDF]
Cells, 2022 The neonatal Fc receptor (FcRn) is highly expressed in the renal proximal tubule and is important for the reclamation of albumin by cellular transcytosis to prevent its loss in the urine. The initial event of this transcellular transport mechanism is the
Eileen Dahlke +4 more
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Integrative structural insights into the IgG-FcRn interactions revealed by engineered FcRn-immobilized affinity chromatography [PDF]
Communications BiologyMolecular interactions between therapeutic antibodies and neonatal Fc receptor (FcRn) are major contributors to the long serum half-life of antibodies. Therefore, the in vitro affinity of IgG for FcRn is an important indicator of in vivo pharmacokinetic ...
Masato Kiyoshi +11 more
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Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpresses FcRn. [PDF]
PLoS ONE, 2012 The neonatal Fc receptor (FcRn) regulates IgG and albumin homeostasis, mediates maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for presentation.
Ana Paula Catunda Lemos +9 more
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Structure of the human astrovirus capsid spike in complex with the neonatal Fc receptor [PDF]
Nature CommunicationsHuman astroviruses (HAstVs) are a leading cause of viral gastroenteritis in children worldwide. Recently the neonatal Fc receptor (FcRn) was identified as a receptor for HAstV, however the molecular basis for the FcRn-HAstV interaction remained unclear ...
Adam Lentz +5 more
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Impact of Neonatal Fc Receptor on Transferrin Receptor Antibody Fusion Protein Pharmacokinetics [PDF]
PharmaceuticsBackground: Transferrin receptor-targeting monoclonal antibodies (TfRMAbs) enhance brain drug delivery by facilitating TfR-mediated transcytosis across the blood–brain barrier (BBB).
Adenike Oyegbesan +3 more
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From promise to practice: evaluating the clinical impact of FcRn inhibition in IgG-mediated autoimmune rheumatic diseases [PDF]
Frontiers in ImmunologyThe neonatal Fragment Crystallizable receptor (FcRn) plays a central role in maintaining immunoglobulin (Ig) G homeostasis by protecting IgG from lysosomal degradation and regulating its transcytosis.
Chu Wei Yang +10 more
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The neonatal Fc receptor expression during macrophage differentiation is related to autophagy
Frontiers in Immunology, 2022 The neonatal Fc receptor (FcRn) plays a central role in recycling and biodistributing immunoglobulin G. FcRn is also involved in many physiological immune functions as well as pathological immune responses in cancer or autoimmune diseases.
Juliette Lamamy +8 more
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FcRn Expression in Endometrial Cancer and Its Association with Clinicopathologic Features
Diagnostics, 2023 Background: Endometrial cancer (EC) has robust molecular diagnostic evidence that correlates well with prognosis. In various types of cancers, FcRn has been identified as an early marker for prognosis.
Dae Hyun Song +5 more
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Frontiers in Microbiology, 2020 Transmissible gastroenteritis virus (TGEV) is a porcine intestinal coronavirus that causes fatal severe watery diarrhea in piglets. The neonatal Fc receptor (FcRn) is the only IgG transport receptor, its expression on mucosal surfaces is triggered upon ...
Shaoju Qian +16 more
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