FcRn-guided antigen trafficking enhances cancer vaccine efficacy
Cancer Immunology, ImmunotherapyThe development of tumor vaccines represents a significant focus within cancer therapeutics research. Nonetheless, the efficiency of antigen presentation in tumor vaccine remains suboptimal.
Mengyu Hong +16 more
doaj +3 more sources
Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove [PDF]
, 2005 Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors.
Bjorkman, Pamela J. +3 more
core +6 more sources
Distribution of FcRn Across Species and Tissues [PDF]
Journal of Histochemistry & Cytochemistry, 2017 The neonatal Fc receptor (FcRn) is a major histocompatibility complex class I type molecule that binds to, transports, and recycles immunoglobulin G (IgG) and albumin, thereby protecting them from lysosomal degradation. Therefore, besides the knowledge of FcRn affinity, FcRn protein expression is critical in understanding the pharmacokinetic behavior ...
Sari, Latvala +4 more
openaire +4 more sources
Does a Polycistronic 2A Design Enable Functional FcRn Production for Antibody Pharmacokinetic Studies? [PDF]
PharmaceuticsNesmeyanova VS +6 more
europepmc +3 more sources
The immune response to malaria in utero. [PDF]
, 2020 Malaria causes tremendous early childhood morbidity and mortality, providing an urgent impetus for the development of a vaccine that is effective in neonates.
Feeney, Margaret E
core +1 more source
Surmounting an Impasse of FcRn Structure [PDF]
Structure, 2013 FcRn, resembling a major histocompatibility complex class I molecule with a closed peptide cleft, is an intracellular molecule that binds endocytosed albumin and IgG by a pH-dependent mechanism, diverting them from degradative fates and moving them out of the cell.
Anderson, Clark L., Kim, Jonghan
openaire +2 more sources
COVID-19 and Pregnancy: Key Findings. [PDF]
Scand J ImmunolMechanistic overview of maternal SARS‐CoV‐2 immunisation, affinity‐matured IgG production, FcRn‐mediated transplacental IgG transport, and antibody delivery to the newborn via fetal circulation and breast milk. The schematic also highlights the translational relevance of murine models, which share conserved mechanisms of antibody induction despite ...
Lima GG +5 more
europepmc +2 more sources
Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine [PDF]
, 2012 The neonatal Fc receptor (FcRn) transports maternal immunoglobulin (IgG) across epithelia to confer passive immunity to mammalian young. In newborn rodents, FcRn transcytoses IgG from ingested milk across the intestinal epithelium for release into the ...
Bjorkman, Pamela J. +2 more
core +2 more sources
THE ROLE OF THE NEONATAL FC RECEPTOR IN THE UNCOATING OF ECHOVIRUSES AND COXSACKIEVIRUS A9
Вопросы вирусологии, 2019 The aim of this study was to determine the role of the human neonatal receptor for the Fc fragment of IgG (hFcRn) as a common uncoating cellular receptor for echoviruses and coxsackievirus A9 during infection of human rhabdomyosarcoma (RD) cells ...
P. S. Usoltseva +4 more
doaj +1 more source
pH Dependence and Stoichiometry of Binding to the Fc Region of IgG by the Herpes Simplex Virus Fc Receptor gE-gI [PDF]
, 2004 Herpes simplex virus type 1 encodes two glycoproteins, gE and gI, that form a heterodimer on the surface of virions and infected cells. The gE-gI heterodimer has been implicated in cell-to-cell spread of virus and is a receptor for the Fc fragment of IgG.
Bjorkman, Pamela J. +2 more
core +1 more source